| Factors affecting gentamicin pharmacokinetics in septic patients. | |
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MedLine Citation:
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PMID: 10456812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This prospective, comparative study was designed to estimate the volume of distribution (Vd) and elimination rate constant (K(e)) of gentamicin and to determine the clinical factors affecting the pharmacokinetics of gentamicin in different stages of sepsis. METHOD: Seventy-seven critically ill patients treated with gentamicin for gram-negative sepsis were included. These septic patients were divided into hyperdynamic septic and hypodynamic septic groups according to cardiac index. Twenty-seven patients who received postoperative prophylactic gentamicin were recruited as controls. RESULTS: Fifty-two patients in the hyperdynamic septic group had a significantly larger Vd than those in the hypodynamic septic and control groups. The Vd was correlated significantly with both Acute Physiological Score (APS) (r=0.340, P<0.01) and cardiac index (r=0.394, P<0.01). The K(e) of gentamicin correlated significantly with both blood urea nitrogen (BUN) (r= 0.565, P<0.01) and serum creatinine level (r=0.563, P<0.01). CONCLUSION: The increased Vd in the septic patients was related to the severity of illness and magnitude of cardiac output. The K(e) of gentamicin was correlated with the serum creatinine level. |
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Authors:
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G J Tang; J J Tang; B S Lin; C W Kong; T Y Lee |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 43 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-09-30 Completed Date: 1999-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 726-30 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Critical Care, Veterans General Hospital-Taipei and National Yang-Ming University, Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Aged Analysis of Variance Anti-Bacterial Agents / pharmacokinetics*, therapeutic use Antibiotic Prophylaxis Blood Urea Nitrogen Cardiac Output / physiology Creatinine / blood Critical Illness Female Gentamicins / pharmacokinetics*, therapeutic use Gram-Negative Bacterial Infections / drug therapy*, metabolism, physiopathology Humans Linear Models Male Metabolic Clearance Rate Middle Aged Postoperative Care Prospective Studies Sepsis / drug therapy*, metabolism, physiopathology Severity of Illness Index Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Gentamicins; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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