| Factors affecting the free fatty acids in rat brain cortex. | |
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MedLine Citation:
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PMID: 20487877 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The mode of free fatty acid (FFA) release from rat brain cortex was examined under various treatments prior to decapitation and at various times after decapitation. Brain FFA are comprised mainly of 16:0, 18:0, 18:1 and 20:4 with smaller amounts of 18:2, 22:4 and 22:6. A biphasic mode of FFA release is observed with respect to post-decapitative ischemic treatment. The initial rapid phase involves a 3-fold increase in 18:0 and 20:4 and this process occurs within the first min of decapitation. The second phase involves a less rapid increase of most fatty acids between 2 and 5 min after decapitation. Besides the ischemia-induced increase in brain FFA, the levels of individual fatty acids are also affected by factors such as handling stress and administration of anesthetic agents. Pentobarbital anesthesia, but not ketamine, caused a partial reduction in 18:0 and 20:4 levels in brain in vivo. Pentobarbital treatment also reduced the rapid phase of FFA increase commencing after decapitation. On the other hand, FFA level was higher in animals subjected to ketamine anesthesia, both during the non-ischemic and ischemic phase. Results obtained from this study indicate that the FFA pool in brain is regulated by a complex mechanism contributed by extrinsic and intrinsic factors. |
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Authors:
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W Tang; G Y Sun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurochemistry international Volume: 4 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 1982 |
Date Detail:
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Created Date: 2010-05-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
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Languages: eng Pagination: 269-73 Citation Subset: - |
Affiliation:
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Sinclair Comparative Medicine Research Farm and Biochemistry Department, University of Missouri, Columbia, MO 65201, U.S.A. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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