| Factors affecting distribution of airflow in a human tracheobronchial cast. | |
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MedLine Citation:
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PMID: 8235126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Air velocity was measured at end airways of hollow replicate casts of the human tracheobronchial tree in order to determine the flow distribution within casts extending to 3 mm diameter airways. Measurements were made by hot-wire anemometry for constant inspiratory flow rates of 7.5, 15, 30 and 60 L.min-1. Average flow distribution among the lung lobes was as follows: right upper, 18.5%; right middle, 9.2%; right lower, 32.3%; left upper, 15.7%; and left lower, 24.3%. An empirical model derived from the experimental flow distribution data demonstrated the effect of various morphometric parameters of the hollow cast on the distribution of airflow. Airway cross-sectional area, branching angle and total path-length were found to have the greatest influence. As the tracheal flow rate decreased from 60 to 7.5 L.min-1, the influence of branching angle was reduced, while total path-length became more influential. These results provide evidence for the transition of flow regimes within the TB tree within normal physiological flow ranges. |
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Authors:
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B S Cohen; R G Sussman; M Lippmann |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiration physiology Volume: 93 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-12-07 Completed Date: 1993-12-07 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 261-78 Citation Subset: IM |
Affiliation:
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Institute of Environmental Medicine, New York University Medical Center, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bronchi / physiology* Humans Male Models, Anatomic* Models, Biological Pulmonary Ventilation / physiology* Trachea / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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CA 13343/CA/NCI NIH HHS; NIEHS ES 00260/ES/NIEHS NIH HHS; NIEHS ES 00881/ES/NIEHS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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