Document Detail


Factors affecting the determination of threshold doses for allergenic foods: how much is too much?
MedLine Citation:
PMID:  11799361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ingestion of small amounts of an offending food can elicit adverse reactions in individuals with IgE-mediated food allergies. The threshold dose for provocation of such reactions is often considered to be zero. However, because of various practical limitations in food production and processing, foods may occasionally contain trace residues of the offending food. Are these very low, residual quantities hazardous to allergic consumers? How much of the offending food is too much? Very little quantitative information exists to allow any risk assessments to be conducted by the food industry. OBJECTIVE: We sought to determine whether the quality and quantity of existing clinical data on threshold doses for commonly allergenic foods were sufficient to allow consensus to be reached on establishment of threshold doses for specific foods. METHODS: In September 1999, 12 clinical allergists and other interested parties were invited to participate in a roundtable conference to share existing data on threshold doses and to discuss clinical approaches that would allow the acquisition of that information. RESULTS: Considerable data were identified in clinical files relating to the threshold doses for peanut, cows' milk, and egg; limited data were available for other foods, such as fish and mustard. CONCLUSIONS: Because these data were often obtained by means of different protocols, the estimation of a threshold dose was very difficult. Development of a standardized protocol for clinical experiments to allow determination of the threshold dose is needed.
Authors:
Steve L Taylor; Susan L Hefle; Carsten Bindslev-Jensen; S Allan Bock; A Wesley Burks; Lynn Christie; David J Hill; Arne Host; Jonathan O'b Hourihane; Gideon Lack; Dean D Metcalfe; Denise Anne Moneret-Vautrin; Peter A Vadas; Fabienne Rance; Daniel J Skrypec; Thomas A Trautman; Ingrid Malmheden Yman; Robert S Zeiger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  109     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-18     Completed Date:  2002-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-30     Citation Subset:  AIM; IM    
Affiliation:
University of Nebraska, Food Allergy Research and Resource Program, Lincoln 68583-0919, USA.
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Food Hypersensitivity / etiology*
Food Industry
Humans
No-Observed-Adverse-Effect Level
Chemical
Reg. No./Substance:
0/Allergens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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