| Factors affecting the angiographic recanalization and early clinical improvement in middle cerebral artery territory infarction after thrombolysis. | |
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MedLine Citation:
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PMID: 15534179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Factors affecting the angiographic recanalization (AR) and clinical improvement (CI) still remain unclear in patients receiving thrombolytic therapy. OBJECTIVES: To elucidate factors related to AR and early CI in patients with middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion. DESIGNS: Retrospective study. SETTING: Department of Neurology, Asan Medical Center, Seoul, South Korea. PATIENTS: We studied 42 patients who (1) underwent diffusion-weighted magnetic resonance (MR) imaging and MR angiography within 6 hours after onset, (2) had MCA territory infarction, (3) had nonvisualization of the MCA or the ICA on initial MR angiography, (4) were treated with thrombolytics, and (5) underwent follow-up MR imaging and MR angiography at day 2 or 3. RESULTS: Successful AR and CI were achieved in 31 and 16 patients, respectively. Angiographic recanalization was related to CI (P<.01), lower follow-up National Institutes of Health Stroke Scale scores (P<.05), the absence of a dominant ipsilateral posterior cerebral artery (P<.01) on initial MR angiography, and the sparing of the internal capsule on both initial (P<.05) and follow-up (P<.01) MR imaging. Clinical improvement was associated with the absence of ICA (vs MCA) flow signals (P<.05), the sparing of the internal capsule (P<.01), and marginally, with the infarct volume change (P = .06). CONCLUSIONS: In patients with MCA or ICA occlusion, CI after thrombolysis is related to the AR and the sparing of the critical motor pathway. The presence of a dominant ipsilateral posterior cerebral artery may predict poor AR after thrombolysis. |
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Authors:
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Jee-Hyun Kwon; Sun U Kwon; Ju H Lee; Choong G Choi; Dae C Suh; Jong S Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of neurology Volume: 61 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-09 Completed Date: 2004-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1682-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology and Radiology, Asan Medical Center, Seoul, South Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carotid Artery Diseases / drug therapy* Cerebral Infarction / drug therapy*, therapy* Cerebrovascular Circulation Female Fibrinolytic Agents / therapeutic use* Health Status Humans Infarction, Middle Cerebral Artery / drug therapy* Magnetic Resonance Angiography* Male Middle Aged Prognosis Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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