| Factors affecting adequacy of Pipelle and Tao Brush endometrial sampling. | |
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MedLine Citation:
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PMID: 18651884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare factors influencing adequacy of endometrial samples obtained using two outpatient sampling devices--Pipelle and Tao Brush. DESIGN: Pragmatic unblinded trial with investigation schedule randomised separately within two groups according to endometrial cancer risk. SETTING: Gynaecology outpatient clinic of a large city hospital in Edinburgh, Scotland. POPULATION: All women referred to a gynaecology outpatient clinic during a 28-month period complaining of abnormal vaginal bleeding. METHODS: Women were assigned to two 'risk groups' for endometrial cancer ('high risk' for postmenopausal women and 'moderate risk' for premenopausal women aged over 40 years or with other risk factors). Women in each risk group had both types of biopsy and were randomised to two outpatient visualisations: hysteroscopy and/or transvaginal ultrasound scan. MAIN OUTCOME MEASURES: Completion of the investigation, adequacy of sample and acceptability of investigation to women. RESULTS: In 200 high-risk women, adequate samples were significantly more likely to be obtained by Tao Brush than Pipelle (P < 0.001). Nulliparity was strongly associated with failed insertion for both devices (P < 0.001). Inadequate samples were strongly associated with postmenopausal status only for Pipelle (P < 0.001), and among premenopausal women, for both samplers, with nulliparity (P < 0.001). A significantly greater proportion of women preferred the Tao Brush to the Pipelle endometrial sampler (P < 0.001). CONCLUSIONS: In postmenopausal women, Tao Brush sampling offers advantages over use of Pipelle, and the former should be considered as an alternative or additional sampling device in this group of women. |
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Authors:
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A R W Williams; S Brechin; A J L Porter; P Warner; H O D Critchley |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 115 ISSN: 1471-0528 ISO Abbreviation: BJOG Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-24 Completed Date: 2008-09-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 1028-36 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, University of Edinburgh Medical School, Royal Infirmary of Edinburgh, Edinburgh, UK. alistair.r.w.williams@ed.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy
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adverse effects,
instrumentation* Endometrial Hyperplasia / pathology Endometrial Neoplasms / pathology Endometrium / pathology* Female Humans Middle Aged Patient Satisfaction Postmenopause Specimen Handling / instrumentation* Uterine Hemorrhage / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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