Document Detail

Factors affecting A-aDo2 after open-heart surgery.
MedLine Citation:
PMID:  945009     Owner:  NLM     Status:  MEDLINE    
Intrapulmonary shunt, cardiac output, and O2 consumption as factors contributing to alveolar-arterial O2 tension difference (A-aDo2) were tested in 11 patients after open-heart surgery. A-aDo2 was well correlated with intrapulmonary shunt, as expected, but no correlation was found between cardiac index (CI) and intrapulmonary shunt. When total shunt (venous admixture) was above 11%, there was an inverse correlation between A-aDo2 and CI, and it was observed that CI falling below 2.5 L/min/sq m contributed significantly to the enlargement of A-aDo2. Low Pao2 (less than 65 torr, breathing air) was characterized by larger arterial-mixed venous O2 content difference than high Pao2 (is greater than 65 torr, on room air), indicating that A-aDo2 was influenced by cardiac output relative to metabolic demand. Intrapulmonary shunt played a main role in increasing A-aDo2 after open-heart surgery, and systemic factors, including changes in cardiac output and O2 consumption, also contributed to development of hypoxia.
A Sari; Y Okuda; H Takeshita; T Oda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  55     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:    1976 May-Jun
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-21     Citation Subset:  IM    
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MeSH Terms
Cardiac Output
Cardiac Surgical Procedures*
Child, Preschool
Oxygen / blood*
Oxygen Consumption*
Pulmonary Alveoli / metabolism*
Pulmonary Circulation
Reg. No./Substance:

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