| Factors affecting Helicobacter pylori eradication using a seven-day triple therapy with a proton pump inhibitor, tinidazole and clarithromycin, in Brazilian patients with peptic ulcer. | |
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MedLine Citation:
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PMID: 11378678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Triple therapy is accepted as the treatment of choice for H. pylori eradication. In industrialized countries, a proton pump inhibitor plus clarithromycin and amoxicillin or nitroimidazole have shown the best results. Our aims were: 1. To study the eradication rate of the association of a proton pump inhibitor plus tinidazole and clarithromycin on H. pylori infection in our population. 2. To determine if previous treatments, gender, age, tobacco, alcohol use, and non-steroidal anti-inflammatory drugs (NSAIDs) change the response to therapy. METHODS: Two hundred patients with peptic ulcer (upper endoscopy) and H. pylori infection (histology and rapid urease test - RUT) were included. A proton pump inhibitor (lanzoprazole 30 mg or omeprazole 20 mg), tinidazole 500 mg, and clarithromycin 250 mg were dispensed twice a day for a seven-day period. Eradication was assessed after 10 to 12 weeks of treatment through histology and RUT. RESULTS: The eradication rate of H. pylori per protocol was 65% (128/196 patients). This rate was 53% for previously treated patients, rising to 76% for not previously treated patients, with a statistical difference p<0.01. No significant difference was observed regarding sex, tobacco use, alcohol consumption, and NSAID use, but for elderly patients the difference was p = 0.05. Adherence to treatment was good, and side effects were mild. CONCLUSIONS: A proton pump inhibitor, tinidazole, and clarithromycin bid for seven days resulted in H. pylori eradication in 65% of the patients. Previous treatments were the main cause of treatment failure. |
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Authors:
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F M Silva; S Zaterka; J N Eisig; E Z Chehter; D Chinzon; A A Laudanna |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista do Hospital das Clínicas Volume: 56 ISSN: 0041-8781 ISO Abbreviation: Rev Hosp Clin Fac Med Sao Paulo Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0415246 Medline TA: Rev Hosp Clin Fac Med Sao Paulo Country: Brazil |
Other Details:
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Languages: eng Pagination: 11-6 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo. |
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents / administration & dosage* Chi-Square Distribution Clarithromycin / administration & dosage* Drug Administration Schedule Drug Therapy, Combination Enzyme Inhibitors / administration & dosage Female Helicobacter Infections / drug therapy* Helicobacter pylori* Humans Logistic Models Male Middle Aged Omeprazole / administration & dosage, analogs & derivatives* Peptic Ulcer / drug therapy*, microbiology Proton Pumps / antagonists & inhibitors* Tinidazole / administration & dosage* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Bacterial Agents; 0/Enzyme Inhibitors; 0/Proton Pumps; 103577-45-3/lansoprazole; 19387-91-8/Tinidazole; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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