Document Detail


Factors affecting Helicobacter pylori eradication using a seven-day triple therapy with a proton pump inhibitor, tinidazole and clarithromycin, in Brazilian patients with peptic ulcer.
MedLine Citation:
PMID:  11378678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Triple therapy is accepted as the treatment of choice for H. pylori eradication. In industrialized countries, a proton pump inhibitor plus clarithromycin and amoxicillin or nitroimidazole have shown the best results. Our aims were: 1. To study the eradication rate of the association of a proton pump inhibitor plus tinidazole and clarithromycin on H. pylori infection in our population. 2. To determine if previous treatments, gender, age, tobacco, alcohol use, and non-steroidal anti-inflammatory drugs (NSAIDs) change the response to therapy. METHODS: Two hundred patients with peptic ulcer (upper endoscopy) and H. pylori infection (histology and rapid urease test - RUT) were included. A proton pump inhibitor (lanzoprazole 30 mg or omeprazole 20 mg), tinidazole 500 mg, and clarithromycin 250 mg were dispensed twice a day for a seven-day period. Eradication was assessed after 10 to 12 weeks of treatment through histology and RUT. RESULTS: The eradication rate of H. pylori per protocol was 65% (128/196 patients). This rate was 53% for previously treated patients, rising to 76% for not previously treated patients, with a statistical difference p<0.01. No significant difference was observed regarding sex, tobacco use, alcohol consumption, and NSAID use, but for elderly patients the difference was p = 0.05. Adherence to treatment was good, and side effects were mild. CONCLUSIONS: A proton pump inhibitor, tinidazole, and clarithromycin bid for seven days resulted in H. pylori eradication in 65% of the patients. Previous treatments were the main cause of treatment failure.
Authors:
F M Silva; S Zaterka; J N Eisig; E Z Chehter; D Chinzon; A A Laudanna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista do Hospital das Clínicas     Volume:  56     ISSN:  0041-8781     ISO Abbreviation:  Rev Hosp Clin Fac Med Sao Paulo     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-05-29     Completed Date:  2001-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0415246     Medline TA:  Rev Hosp Clin Fac Med Sao Paulo     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo.
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage*
Chi-Square Distribution
Clarithromycin / administration & dosage*
Drug Administration Schedule
Drug Therapy, Combination
Enzyme Inhibitors / administration & dosage
Female
Helicobacter Infections / drug therapy*
Helicobacter pylori*
Humans
Logistic Models
Male
Middle Aged
Omeprazole / administration & dosage,  analogs & derivatives*
Peptic Ulcer / drug therapy*,  microbiology
Proton Pumps / antagonists & inhibitors*
Tinidazole / administration & dosage*
Treatment Outcome
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Bacterial Agents; 0/Enzyme Inhibitors; 0/Proton Pumps; 103577-45-3/lansoprazole; 19387-91-8/Tinidazole; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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