| Factors predicting vitamin D response variation in non-Hispanic white postmenopausal women. | |
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MedLine Citation:
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PMID: 22585090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: It is well documented that there is wide variation in the response of serum 25-hydroxyvitamin D [25(OH)D] to a given dose of vitamin D supplementation. Understanding factors affecting the response variation is important for identifying subjects who are susceptible to vitamin D deficiency or toxicity. This study aimed to evaluate potential predictors for vitamin D response variation. DESIGN AND PARTICIPANTS: A total of 1179 non-Hispanic white postmenopausal women were enrolled into a 4-yr calcium and vitamin D (1100 IU/d) clinical trial. Among them, serum 25(OH)D level of 1063 subjects were measured at both baseline and after 12 months treatment. Vitamin D response was computed for these 1063 subjects as the difference in levels of serum 25(OH)D concentration at the end of a 12-month vitamin D treatment compared with baseline. Stepwise linear regression was used to identify predictors of vitamin D response variation. RESULTS: Increase in vitamin D intake, baseline serum 25(OH)D level, baseline blood collection season, baseline serum calcium level, and baseline body mass index were predictors of vitamin D response variation. These five factors explained 46.8% of the vitamin D response variation in the 1063 subjects. The first three factors [increase in vitamin D intake, baseline serum 25(OH)D level, baseline blood collection season] remained as predictors in the 392 subjects with trial vitamin D supplementation. For the first time, our study indicated that season is an important prediction factor for vitamin D response variation. Subjects who started vitamin D treatment in a cold season (autumn and winter) achieved a significantly higher serum 25(OH)D increase than those started in a hot season (summer) (P < 0.001). CONCLUSION: Our study suggests that the increase in vitamin D supplementation, baseline serum 25(OH)D level, and the season when initiating the vitamin D supplementation can partially predict vitamin D response variation in non-Hispanic postmenopausal women. |
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Authors:
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Lan-Juan Zhao; Yu Zhou; Fengxiao Bu; Dianne Travers-Gustafson; An Ye; Xiaojing Xu; Lee Hamm; Daniel Michael Gorsage; Xiang Fang; Hong-Wen Deng; Robert R Recker; Joan M Lappe |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-05-14 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 97 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-07 Completed Date: 2012-10-24 Revised Date: 2013-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2699-705 Citation Subset: AIM; IM |
Affiliation:
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Department of Biostatistics and Bioinformatics, Center for Bioinformatics and Genomics, Tulane University, New Orleans, Louisiana 70112, USA. lzhao2@tulane.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Dietary Supplements Double-Blind Method Female Humans Middle Aged Postmenopause / metabolism* Regression Analysis Seasons Vitamin D / administration & dosage*, analogs & derivatives*, blood |
| Grant Support | |
ID/Acronym/Agency:
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3R01CA129488-01A2S2/CA/NCI NIH HHS; P50 AR055081/AR/NIAMS NIH HHS; R01 AR057049/AR/NIAMS NIH HHS; R01AG026564/AG/NIA NIH HHS; R01AR050496/AR/NIAMS NIH HHS; R01AR057049/AR/NIAMS NIH HHS; R03TW008221/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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