| Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries). | |
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MedLine Citation:
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PMID: 20859975 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Synthetic organic reactions are a fundamental enabler of small-molecule drug discovery, and the vast majority of medicinal chemists are initially trained--either at universities or within industry--as synthetic organic chemists. The sheer breadth of synthetic methodology available to the medicinal chemist represents an almost endless source of innovation. But what reactions do medicinal chemists use in drug discovery? And what criteria do they use in selecting synthetic methodology? Why are arrays (small focused libraries) so powerful in the lead-optimization process? In this Minireview, we suggest some answers to these questions and also describe how we have tried to expand the number of robust reactions available to the medicinal chemist. |
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Authors:
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Tony W J Cooper; Ian B Campbell; Simon J F Macdonald |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: 49 ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: Germany |
Other Details:
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Languages: eng Pagination: 8082-91 Citation Subset: IM |
Affiliation:
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Respiratory CEDD, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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