Document Detail


Factors Determining Diagnostic Yield of Endoscopic Ultrasound Guided Fine-Needle Aspiration for Pancreatic Cystic Lesions: A Multicentre Asian Study.
MedLine Citation:
PMID:  23314918     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND AIM: The purpose of this study was to determine (1) the diagnostic yield for endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in patients with pancreatic cystic lesions, (2) additional value of EUS-FNA over EUS alone in the diagnosis of pancreatic cysts, and (3) diagnostic sensitivity and specificity of EUS and EUS-FNA in the subset of patients where histopathology of surgical specimens were available. METHODS: All patients who underwent EUS examination for the evaluation of pancreatic cystic lesions in six Asian centres were included in the study. RESULTS: Of 298 patients with pancreatic cysts who underwent EUS, 132 (44.3 %) underwent FNA. In the entire cohort, pseudocysts and intraductal papillary mucinous neoplasm (IPMN) were the predominant cystic lesions. The cytologic yield of EUS-FNA was 47 %. On univariate analysis, factors associated with higher cytologic yield included vascular involvement on EUS, presence of solid cystic component, and increased number of needle passes during EUS-FNA. On multivariate analysis, presence of solid cystic components and increased number of needle passes during EUS-FNA were associated with higher diagnostic yield of EUS-FNA. For pancreatic cysts with a solid component, the diagnostic yield of EUS-FNA increased significantly from 44 % with one pass to 78 % with more than one pass (p = 0.016). In the absence of a solid component, the diagnostic yield was 29 % with one pass and was not significantly different from the diagnostic yield of 50 % with more than one pass, p = 0.081. CONCLUSION: The cytologic yield of EUS-FNA was 47 %. When a solid component was present in the cyst, doing more than one pass during EUS-FNA increased its diagnostic yield.
Authors:
Lee Guan Lim; Sandeep Lakhtakia; Tiing Leong Ang; Charles K F Vu; Frederick Dy; Vui Heng Chong; Christopher J L Khor; Wee Chian Lim; Bhavesh Kishor Doshi; Shyam Varadarajulu; Kenjiro Yasuda; Jennie Y Y Wong; Yiong Huak Chan; Min En Nga; Khek Yu Ho;
Related Documents :
16615828 - A review of diagnosis and modes of presentation of tropical idiopathic lower limb gangr...
20974788 - Reliability of clinical examinations for pediatric skin and soft-tissue infections.
319538 - Observations on the diagnosis and treatment of schistosomiasis in an endemic area.
7087818 - Pathology in the lower half of the functional face - its significance in clinical medic...
17204108 - Bullous eosinophilic cellulitis succession with eosinophilic pustular folliculitis with...
15098778 - Nodular melanoma of the face: a rare finding in african americans.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  -     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Gastroenterology and Hepatology, National University Health System, 10 Kent Ridge Crescent, Singapore, 119260, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer.
Next Document:  Predictive Risk Factors of Cardiorespiratory Abnormality for Upper Gastrointestinal Endoscopy in Tib...