| Factors associated with nonadherence to medication in kidney transplant recipients. | |
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MedLine Citation:
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PMID: 20689323 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Nonadherence in kidney transplant recipients was evaluated in this report using a questionnaire with five binary questions and one question on a continuous scale. Study participants at the University of Utah Transplant Program (n = 199) were 43.0 ± 14.2 years old; 67% were males, and 81% were White. Two questions that produced heterogeneous outcome were analyzed: 'Do you ever forget to take your medication?' (79% no, 21% yes) and 'Have you ever taken your medications late?' (67% no, 33% yes). Responses to these questions correlated (χ² 65.2, p < 0.001; correlation coefficient 0.57, p < 0.001). We performed a logistic regression analysis to identify factors associated with the combined outcome of forgetting/not taking medications altogether or taking medications off schedule. Higher comorbidity index [odds ratio (OR) 2.19, p < 0.001], living (compared to deceased) donor (OR 2.81, p = 0.005) and full-time employment were associated with forgetting medications or taking them late (OR 3.12, p = 0.01). Recipient age tended to be associated with lower risk of nonadherence, but did not reach statistical significance (OR 0.98 per year of age, p = 0.13). Education level, smoking status, recipient race, dialysis modality, number of medications and the time since first kidney transplantation were not associated with the outcome. In conclusion, renal transplant recipients with greater comorbidity, receiving kidney from a living donor and with full-time employment reported lower levels of medication adherence. |
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Authors:
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Alexander S Goldfarb-Rumyantzev; Seth Wright; Regina Ragasa; Doug Ostler; Jennifer Van Orden; Lonnie Smith; Ekaterina Efimova; Lyska Emerson; Gurprataap Singh Sandhu; Fuad Shihab |
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Publication Detail:
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Type: Journal Article Date: 2010-08-03 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 117 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c33-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass., USA. agoldfar@bidmc.harvard.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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