Document Detail


Factors associated with early severe intraventricular haemorrhage in very low birth weight infants.
MedLine Citation:
PMID:  20221958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to identify factors associated with early IVH grades III-IV in the first 72 h of life in very low birth weight (VLBW) preterm infants. METHODS: A case-control study was performed in 28 preterm infants and 55 controls. The mean of all blood gas determinations, presence of arterial hypotension, variables related to mechanical ventilation, as well as antenatal and neonatal comorbidities during the first 3 days of life were evaluated. RESULTS: The proportion of infants with pH<7.2, PaCO (2) >55 mmHg and arterial hypotension was higher in the case group. PaCO (2) >55 mmHg was more frequently found in patients with IVH grades III (16.6 vs. 1.8%; p=0.03) and IV (37.5 vs. 1.8%; p=0.0001) than in controls, respectively. Gestational age (beta=-0.30; p=0.04), BE (beta=0.33; p=0.0005) and arterial hypotension (beta=0.40; p=0.00003) were associated to both grades of IVH (R (2)=0.39; p<0.0001 for the model). However, only birth weight and arterial hypotension were identified as factors related to IVH grade III (R (2)=0.44; p=0.0001 for the model) and PaCO (2) >55 mmHg, and BE as factors for IVH grade IV (R (2)=0.32; p=0.0003 for the model). CONCLUSION: Birth weight and arterial hypotension were factors related to early IVH grade III, whereas hypercapnia and large BE were factors related to IVH grade IV in VLBW infants.
Authors:
M M Vela-Huerta; M Amador-Licona; N Medina-Ovando; C Aldana-Valenzuela
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Publication Detail:
Type:  Journal Article     Date:  2010-03-10
Journal Detail:
Title:  Neuropediatrics     Volume:  40     ISSN:  1439-1899     ISO Abbreviation:  Neuropediatrics     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  224-7     Citation Subset:  IM    
Copyright Information:
(c) Georg Thieme Verlag KG Stuttgart . New York.
Affiliation:
Department of Neonatology of the Hospital of Gynecology and Obstetrics in the Mexican Institute of Social Security, Leon, Mexico. mmavehu@yahoo.com.mx
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Cerebral Hemorrhage / classification,  etiology*,  pathology*
Cerebral Ventricles / pathology*
Female
Humans
Infant, Newborn
Infant, Very Low Birth Weight*
Logistic Models
Male
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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