| Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis. | |
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MedLine Citation:
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PMID: 21540006 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND/PURPOSE: Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such as interleukin (IL)-10, IL-12, IL-18, and clinical diseases; but the relative importance of each factor is unclear. METHODS: We evaluated the effects of these factors in 46 healthy individuals, 81 patients with TB, and 88 patients with non-TB pneumonia. The responses of IFN-γ, IL-10, IL-12 and IL-18 were determined from phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMCs). RESULTS: General linear model analysis showed that disease status and IL-12 response were the independent factors associated with the IFN-γ response. The production of IFN-γ was not affected by IL-10 and IL-18. There was a significant relationship between the IFN-γ response and the IL-12 response among patients with non-TB pneumonia, patients with TB, and healthy participants (Pearson's correlation coefficients of 0.466, 0.483, and 0.464, respectively). CONCLUSION: Production of IFN-γ in PBMCs was associated with active pulmonary TB and IL-12 response. |
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Authors:
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Chung-Chieh Yu; Yu-Chih Liu; Chien-Ming Chu; Duen-Yau Chuang; Wen-Chen Wu; Huang-Pin Wu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 110 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-05-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 239-46 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Division of Pulmonary Medicine, Chang Gung Memorial Hospital, Keelung, Chang Gung University College of Medicine, Taoyuan, Taiwan; Department of Respiratory Therapy, Chang Gung Memorial Hospital, Keelung, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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