Document Detail


Factors affecting growth in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial.
MedLine Citation:
PMID:  21784436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To describe growth patterns in infants with single ventricle physiology and determine factors influencing growth.
STUDY DESIGN: Data from 230 subjects enrolled in the Pediatric Heart Network Infant Single Ventricle Enalapril Trial were used to assess factors influencing change in weight-for-age z-score (z) from study enrollment (0.7 ± 0.4 months) to pre-superior cavopulmonary connection (SCPC; 5.1 ± 1.8 months, period 1) and pre-SCPC to final study visit (14.1 ± 0.9 months, period 2). Predictor variables included patient characteristics, feeding regimen, clinical center, and medical factors during neonatal (period 1) and SCPC hospitalizations (period 2). Univariate regression analysis was performed, followed by backward stepwise regression and bootstrapping reliability to inform a final multivariable model.
RESULTS: Weights were available for 197 of 230 subjects for period 1 and 173 of 197 subjects for period 2. For period 1, greater gestational age, younger age at study enrollment, tube feeding at neonatal hospitalization discharge, and clinical center were associated with a greater negative z (poorer growth) in multivariable modeling (adjusted R(2) = 0.39, P < .001). For period 2, younger age at SCPC and greater daily caloric intake were associated with greater positive z (better growth; R(2) = 0.10, P = .002).
CONCLUSIONS: Aggressive nutritional support and earlier SCPC are modifiable factors associated with a favorable change in weight-for-age z-score.
Authors:
Richard V Williams; Victor Zak; Chitra Ravishankar; Karen Altmann; Jeffrey Anderson; Andrew M Atz; Carolyn Dunbar-Masterson; Nancy Ghanayem; Linda Lambert; Karen Lurito; Barbara Medoff-Cooper; Renee Margossian; Victoria L Pemberton; Jennifer Russell; Mario Stylianou; Daphne Hsu;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2011-07-23
Journal Detail:
Title:  The Journal of pediatrics     Volume:  159     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2011-12-30     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1017-22.e2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. richard.williams@imail.org
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00113087
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Enalapril / therapeutic use
Female
Growth Disorders / etiology*
Heart Defects, Congenital / complications*
Humans
Infant
Infant, Newborn
Male
Prospective Studies
Grant Support
ID/Acronym/Agency:
U01 HL068269/HL/NHLBI NIH HHS; U01 HL068269-10/HL/NHLBI NIH HHS; U01 HL068270/HL/NHLBI NIH HHS; U01 HL068270-08/HL/NHLBI NIH HHS; U01 HL068279/HL/NHLBI NIH HHS; U01 HL068279-05/HL/NHLBI NIH HHS; U01 HL068281/HL/NHLBI NIH HHS; U01 HL068281-06/HL/NHLBI NIH HHS; U01 HL068285/HL/NHLBI NIH HHS; U01 HL068285-05/HL/NHLBI NIH HHS; U01 HL068288/HL/NHLBI NIH HHS; U01 HL068288-10/HL/NHLBI NIH HHS; U01 HL068290/HL/NHLBI NIH HHS; U01 HL068290-06/HL/NHLBI NIH HHS; U01 HL068292/HL/NHLBI NIH HHS; U01 HL068292-10/HL/NHLBI NIH HHS; U01 HL085057/HL/NHLBI NIH HHS; U01 HL085057-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril
Investigator
Investigator/Affiliation:
Gail Pearson / ; Victoria Pemberton / ; Mario Stylianou / ; Marsha Mathis / ; Lynn Mahony / ; Lynn Sleeper / ; Steven Colan / ; Lisa Virzi / ; Lisa Wruck / ; Victor Zak / ; David F Teitel / ; Jane Newburger / ; Roger Breitbart / ; Jami Levine / ; Ellen McGrath / ; Carolyn Dunbar-Masterson / ; Daphne Hsu / ; William Hellenbrand / ; Ashwin Prakash / ; Darlene Servedio / ; Victoria L Vetter / ; Sarah Tabbutt / ; Katherine Lee / ; Marisa Nolan / ; Stephanie Piacentino / ; D Woodrow Benson / ; Catherine Dent / ; Lois Bogenschutz / ; Teresa Barnard / ; Steven Schwartz / ; David Nelson / ; Page A W Anderson / ; Wesley Covitz / ; Kari Crawford / ; Michael Hines / ; James Jaggers / ; Theodore Koutlas / ; Jennifer Li / ; Charlie Sang / ; Lori Jo Sutton / ; Mingfen Xu / ; J Philip Saul / ; Andrew Atz / ; Girish Shirali / ; Teresa Atz / ; LuAnn Minich / ; Richard Williams / ; Linda Lambert / ; John Hawkins / ; Marian Sharrow / ; Brian McCrindle / ; Elizabeth Radojewski / ; Nancy Slater / ; Svetlana Khaikin / ; Susan McIntyre / ; Nancy Ghanayem / ; Kathy Mussatto / ; Michele Frommelt / ; Lisa Young-Borkowski / ; Albert Rocchini / ; Laurie Rodgers-Augustyniak / ; Steven Colan / ; Renee Margossian / ; Wendy Chung / ; Liyong Deng / ; Patricia Lanzano / ; Michael Artman / ; Judith Massicot-Fisher / ; Timothy Feltes / ; Julie Johnson / ; Thomas Klitzner / ; Jeffrey Krischer / ; G Paul Matherne / ; John Kugler / ; Rae-Ellen Kavey / ; David J Driscoll / ; Mark Galantowicz / ; Sally A Hunsberger / ; Thomas J Knight / ; Holly Taylor / ; Catherine L Webb /
Comments/Corrections

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