| Factors affecting growth in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial. | |
| | |
MedLine Citation:
|
PMID: 21784436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To describe growth patterns in infants with single ventricle physiology and determine factors influencing growth. STUDY DESIGN: Data from 230 subjects enrolled in the Pediatric Heart Network Infant Single Ventricle Enalapril Trial were used to assess factors influencing change in weight-for-age z-score (z) from study enrollment (0.7 ± 0.4 months) to pre-superior cavopulmonary connection (SCPC; 5.1 ± 1.8 months, period 1) and pre-SCPC to final study visit (14.1 ± 0.9 months, period 2). Predictor variables included patient characteristics, feeding regimen, clinical center, and medical factors during neonatal (period 1) and SCPC hospitalizations (period 2). Univariate regression analysis was performed, followed by backward stepwise regression and bootstrapping reliability to inform a final multivariable model. RESULTS: Weights were available for 197 of 230 subjects for period 1 and 173 of 197 subjects for period 2. For period 1, greater gestational age, younger age at study enrollment, tube feeding at neonatal hospitalization discharge, and clinical center were associated with a greater negative z (poorer growth) in multivariable modeling (adjusted R(2) = 0.39, P < .001). For period 2, younger age at SCPC and greater daily caloric intake were associated with greater positive z (better growth; R(2) = 0.10, P = .002). CONCLUSIONS: Aggressive nutritional support and earlier SCPC are modifiable factors associated with a favorable change in weight-for-age z-score. |
| | |
Authors:
|
Richard V Williams; Victor Zak; Chitra Ravishankar; Karen Altmann; Jeffrey Anderson; Andrew M Atz; Carolyn Dunbar-Masterson; Nancy Ghanayem; Linda Lambert; Karen Lurito; Barbara Medoff-Cooper; Renee Margossian; Victoria L Pemberton; Jennifer Russell; Mario Stylianou; Daphne Hsu; |
Related Documents
:
|
20950966 - Auditory processing during sleep in preterm infants: an event related potential study. 363996 - Sequelae of caffeine treatment in preterm infants with apnea. 10568416 - Nonvagal tachypnea following alpha2-adrenoceptor stimulation in awake goats. 2771466 - Periodic breathing parameter values depend on specific pneumogram scoring criteria. 12223246 - Seasonal fluctuation in birthweight in schizophrenia. 20843526 - The need for quality improvement in sweat testing infants after newborn screening for c... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2011-07-23 |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 159 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: 2011-12-30 Revised Date: 2013-02-19 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 1017-22.e2 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. richard.williams@imail.org |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00113087 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin-Converting Enzyme Inhibitors
/
therapeutic use Enalapril / therapeutic use Female Growth Disorders / etiology* Heart Defects, Congenital / complications* Humans Infant Infant, Newborn Male Prospective Studies |
| Grant Support | |
ID/Acronym/Agency:
|
U01 HL068269/HL/NHLBI NIH HHS; U01 HL068269-10/HL/NHLBI NIH HHS; U01 HL068270/HL/NHLBI NIH HHS; U01 HL068270-08/HL/NHLBI NIH HHS; U01 HL068279/HL/NHLBI NIH HHS; U01 HL068279-05/HL/NHLBI NIH HHS; U01 HL068281/HL/NHLBI NIH HHS; U01 HL068281-06/HL/NHLBI NIH HHS; U01 HL068285/HL/NHLBI NIH HHS; U01 HL068285-05/HL/NHLBI NIH HHS; U01 HL068288/HL/NHLBI NIH HHS; U01 HL068288-10/HL/NHLBI NIH HHS; U01 HL068290/HL/NHLBI NIH HHS; U01 HL068290-06/HL/NHLBI NIH HHS; U01 HL068292/HL/NHLBI NIH HHS; U01 HL068292-10/HL/NHLBI NIH HHS; U01 HL085057/HL/NHLBI NIH HHS; U01 HL085057-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril |
| Investigator | |
Investigator/Affiliation:
|
Gail Pearson / ; Victoria Pemberton / ; Mario Stylianou / ; Marsha Mathis / ; Lynn Mahony / ; Lynn Sleeper / ; Steven Colan / ; Lisa Virzi / ; Lisa Wruck / ; Victor Zak / ; David F Teitel / ; Jane Newburger / ; Roger Breitbart / ; Jami Levine / ; Ellen McGrath / ; Carolyn Dunbar-Masterson / ; Daphne Hsu / ; William Hellenbrand / ; Ashwin Prakash / ; Darlene Servedio / ; Victoria L Vetter / ; Sarah Tabbutt / ; Katherine Lee / ; Marisa Nolan / ; Stephanie Piacentino / ; D Woodrow Benson / ; Catherine Dent / ; Lois Bogenschutz / ; Teresa Barnard / ; Steven Schwartz / ; David Nelson / ; Page A W Anderson / ; Wesley Covitz / ; Kari Crawford / ; Michael Hines / ; James Jaggers / ; Theodore Koutlas / ; Jennifer Li / ; Charlie Sang / ; Lori Jo Sutton / ; Mingfen Xu / ; J Philip Saul / ; Andrew Atz / ; Girish Shirali / ; Teresa Atz / ; LuAnn Minich / ; Richard Williams / ; Linda Lambert / ; John Hawkins / ; Marian Sharrow / ; Brian McCrindle / ; Elizabeth Radojewski / ; Nancy Slater / ; Svetlana Khaikin / ; Susan McIntyre / ; Nancy Ghanayem / ; Kathy Mussatto / ; Michele Frommelt / ; Lisa Young-Borkowski / ; Albert Rocchini / ; Laurie Rodgers-Augustyniak / ; Steven Colan / ; Renee Margossian / ; Wendy Chung / ; Liyong Deng / ; Patricia Lanzano / ; Michael Artman / ; Judith Massicot-Fisher / ; Timothy Feltes / ; Julie Johnson / ; Thomas Klitzner / ; Jeffrey Krischer / ; G Paul Matherne / ; John Kugler / ; Rae-Ellen Kavey / ; David J Driscoll / ; Mark Galantowicz / ; Sally A Hunsberger / ; Thomas J Knight / ; Holly Taylor / ; Catherine L Webb / |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature in...
Next Document: An Evaluation of a Clinical Approach to Staging Tobacco Addiction.