Document Detail


Factorial design approach to evaluate interactions between electrically assisted enhancement and skin stripping for delivery of tacrine.
MedLine Citation:
PMID:  15710505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this work was to study the mechanisms of action of iontophoresis and electroporation and their interaction effects on delivery of tacrine hydrochloride in vitro across intact and stripped rat skin. Experiments were done according to a full factorial design, to quantify the effects of iontophoresis (X1), electroporation (X2) and stripped skin (X3) alone and in combination on cumulative drug delivery at 6 h. Mathematical model eliciting the main effects of the factors and their interaction on cumulative tacrine delivery in 6 h shows that all three techniques examined alone have a positive impact on the permeation of tacrine, the greatest enhancement in delivery achieved by iontophoresis. However, iontophoresis in combination with electroporation or skin stripping yielded no improvement in delivery compared to iontophoresis alone. The most significant enhancement is seen when all three methods of assisted delivery are done in combination. Iontophoresis appears to control drug delivery to the exclusion of other enhancement methods. Electroporation appears to cause formation of a large depot of tacrine in the skin.
Authors:
Adina C Hirsch; Rashmi S Upasani; Ajay K Banga
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-18
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  103     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-21     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, 3001 Mercer University Drive, School of Pharmacy, Atlanta, GA 30341, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Delivery Systems / methods*
Drug Evaluation, Preclinical / methods
Electroporation / methods
Iontophoresis / methods*
Models, Chemical
Rats
Research Design*
Skin Absorption / physiology*
Tacrine / administration & dosage,  metabolism*
Chemical
Reg. No./Substance:
321-64-2/Tacrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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