Document Detail

Factor analysis, including antihypertensive medication, of the outcome of pregnancy in pregnancy-associated hypertension.
MedLine Citation:
PMID:  11435745     Owner:  NLM     Status:  MEDLINE    
AIM: To study the influence of different maternal factors, including antihypertensive medication, on the outcome of pregnancy in primi- and multiparas with pregnancy-associated hypertension. METHODS: A retrospective, multiple-variate analysis was undertaken of the influence of several maternal factors, including antihypertensive medication, on fetal death and Apgar scores and the correlation between the medication and the number of caesarean sections in 127 episodes of pregnancy-associated hypertension was studied for the whole group as well as for primi- and multiparas separately. Of the multiparas, 40.8% had a history of preeclampsia, 19.7% of chronic hypertension and 9.2% of diabetes mellitus. Antihypertensive treatment aimed at achieving a blood pressure of 140/90 mm Hg. Forty-one patients (32.3%) received intravenous hydralazine, 25 (19.7%) received nifedipine per os and 44 (34.6%) received labetalol per os. RESULTS: The maximum systolic and diastolic blood pressure in the patients given intravenous hydralazine, nifedipine per os or labetalol per os did not differ, whereas in the multiparas, the number of patients who reached the target blood pressure while using labetalol was higher than with the two other medications, especially in comparison with intravenous hydralazine. For the primiparas, the time of delivery was the only factor with a significant impact on the Apgar scores. In the multiparas, there was an additional negative influence of the use of intravenous hydralazine. This was not seen in the patients using nifedipine and labetalol. CONCLUSIONS: The results suggest that in multiparas, intravenous hydralazine is possibly associated with more fetal distress when compared to primiparas.
M Hussein; J M Mooij; H Roujouleh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  24     ISSN:  1420-4096     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2001  
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  124-8     Citation Subset:  IM    
Department of Nephrology, Dialysis and Hypertension, Al Hada Armed Forces Hospital, Taif, Saudi Arabia.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Apgar Score
Cesarean Section / statistics & numerical data
Disease Susceptibility
Fetal Death / epidemiology
Hydralazine / therapeutic use
Hypertension / drug therapy,  epidemiology*
Infant, Newborn
Labetalol / therapeutic use
Multivariate Analysis
Nifedipine / therapeutic use
Pre-Eclampsia / drug therapy,  epidemiology
Pregnancy Complications, Cardiovascular / drug therapy,  epidemiology*
Pregnancy Outcome
Pregnancy in Diabetics / epidemiology
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents; 21829-25-4/Nifedipine; 36894-69-6/Labetalol; 86-54-4/Hydralazine

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