| Factor analysis identifies subgroups of constipation. | |
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MedLine Citation:
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PMID: 21472106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction. METHODS: One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item, wide-ranging self-report questionnaire. One hundred of these patients had colonic transit measured scintigraphically. Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology. Cluster analysis was used to determine whether individual patients naturally group into distinct subtypes. RESULTS: Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors. Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit, irritable bowel syndrome positive criteria and regular stool frequency. The majority of patients with these characteristics also reported regular laxative use. CONCLUSION: Factor analysis identified four constipation subgroups, based on severity and laxative unresponsiveness, in a constipated population. However, clear stratification into clinically identifiable groups remains imprecise. |
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Authors:
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Philip G Dinning; Mike Jones; Linda Hunt; Sergio E Fuentealba; Jamshid Kalanter; Denis W King; David Z Lubowski; Nicholas J Talley; Ian J Cook |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-07-25 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1468-74 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, St. George Hospital, University of New South Wales, Kogarah, NSW 2217, Australia. p.dinning@unsw.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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etiology Adolescent Adult Aged Aged, 80 and over Cluster Analysis Colon / physiopathology, radionuclide imaging Constipation / classification*, complications, diagnosis, drug therapy, physiopathology Defecation Factor Analysis, Statistical Female Gastrointestinal Transit Humans Laxatives / therapeutic use Male Middle Aged New South Wales Questionnaires Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Laxatives |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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