Document Detail

Factor XII deficiency and pregnancy.
MedLine Citation:
PMID:  1870803     Owner:  NLM     Status:  MEDLINE    
A 19-year-old primigravida with known factor XII deficiency (prepregnant factor XII level of 21%) presented with placental abruption and preterm labor at 26 weeks' gestation. A healthy 925-g female infant was born by spontaneous vaginal delivery. The mother had no postpartum hemorrhage or further complications, and the infant demonstrated no intracranial or other forms of hemorrhage up to 70 days of age. The infant's factor XII level was 34% (normal for her age). There are only two previous reports of factor XII deficiency in pregnancy cited in the English literature, and both were uncomplicated. In view of the risk of thromboembolic complications in nonpregnant individuals with factor XII deficiency, pregnant women with a prolonged activated partial thromboplastin time and no lupus anticoagulant or anticardiolipin antibody syndrome should also be investigated for deficiencies of factors VIII, IX, and XII. These patients should be given the appropriate counseling and should be monitored for features of thromboembolism if factor XII deficiency is confirmed.
T T Lao; R M Lewinsky; A Ohlsson; H Cohen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  78     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-09-16     Completed Date:  1991-09-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-3     Citation Subset:  AIM; IM    
Regional Perinatal Unit, Women's College Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Abruptio Placentae / etiology*
Factor XII Deficiency / complications*
Infant, Newborn
Infant, Premature / physiology
Labor, Induced
Obstetric Labor, Premature
Pregnancy Complications, Hematologic*

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