Document Detail

Review: Factor XI deficiency: review and management in pregnant women.
MedLine Citation:
PMID:  19049995     Owner:  NLM     Status:  MEDLINE    
Factor XI deficiency is a rare disease found predominantly in Ashkenazi Jews. There is a poor correlation between factor XI level and bleeding in patients with factor XI deficiency. Individuals with severe factor XI deficiency are usually at risk of excessive bleeding after surgery and injury, particularly when trauma involves tissues rich in fibrinolytic activity. Women with partial or severe deficiency are at risk of excessive uterine bleeding during labor. The unpredictable nature of factor XI deficiency complicates management during pregnancy and delivery. This review gives an overview of the management of pregnant women with factor XI deficiency.
Monica Mart?n-Salces; Victor Jimenez-Yuste; Mar?a Teresa Alvarez; Manuel Quintana; Fernando Hern?ndez-Navarro
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-12-01
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  16     ISSN:  1938-2723     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Haemophilia Unit, Haematology Department, Hospital Universitario La Paz, Paseo de la Castellana 261, Madrid, Spain.
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MeSH Terms
Anesthesia, Epidural / contraindications
Anesthesia, Obstetrical / methods
Anesthesia, Spinal / contraindications
Blood Loss, Surgical
Cesarean Section
Deamino Arginine Vasopressin / therapeutic use
Factor XI / genetics,  therapeutic use
Factor XI Deficiency* / drug therapy,  ethnology,  genetics
Infant, Newborn
Jews / genetics
Postoperative Hemorrhage / prevention & control
Postpartum Hemorrhage / prevention & control
Pregnancy Complications, Hematologic / drug therapy,  genetics,  therapy*
Uterine Hemorrhage / prevention & control
Reg. No./Substance:
16679-58-6/Deamino Arginine Vasopressin; 9013-55-2/Factor XI

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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