| Factor VIII-von Willebrand factor in giant cell arteritis and polymyalgia rheumatica. | |
| | |
MedLine Citation:
|
PMID: 3925247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Levels of three factor VIII-von Willebrand factor components (von Willebrand antigen, ristocetin cofactor, and factor VIII coagulant) were higher in specimens of plasma from 27 patients with giant cell arteritis and 18 patients with polymyalgia rheumatica than in specimens from 21 normal control subjects. Values in patients with active giant cell arteritis were higher than those in patients with either inactive giant cell arteritis or active polymyalgia rheumatica. Levels of factor VIII-von Willebrand factor components tended to decline gradually after disease activity had been suppressed by corticosteroid therapy and therefore may be indicators of vascular damage. These levels, however, did not revert to normal rapidly in response to corticosteroid therapy as did the patients' symptoms and the usual laboratory measurements indicative of inflammation; thus, measurements of these components are unlikely to be useful in day-to-day management of these diseases. Electrophoretic analysis suggested that the elevated values are due to increased amounts of normal factor VIII-von Willebrand factor rather than to the presence of an abnormal molecule. |
| | |
Authors:
|
S T Persellin; T M Daniels; L J Rings; F J Kazmier; E J Bowie; G G Hunder |
Related Documents
:
|
8192147 - Rapid improvement of coagulopathy by all-trans retinoic acid in acute promyelocytic leu... 11167227 - Fibrinogen and detached retina with or without proliferation. 17976427 - Hereditary angioedema with normal c1 inhibitor: clinical symptoms and course. 3931287 - Effect of stanozolol on factors viii and ix and serum aminotransferases in haemophilia. 18317847 - Why don't diabetes patients achieve recommended risk factor targets? poor adherence ver... 8909757 - Use of invasive cardiovascular monitoring in patients with burns greater than 30 per ce... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Mayo Clinic proceedings. Mayo Clinic Volume: 60 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 1985 Jul |
Date Detail:
|
Created Date: 1985-08-19 Completed Date: 1985-08-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 457-62 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antigens / analysis Blood Coagulation Factors / analysis* Blood Protein Electrophoresis Blood Sedimentation Factor VIII / analysis* Giant Cell Arteritis / blood* Hemoglobins / analysis Humans Middle Aged Platelet Count Polymyalgia Rheumatica / blood* von Willebrand Factor / analysis*, immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 0/Blood Coagulation Factors; 0/Hemoglobins; 0/Von Willebrand antigen; 0/von Willebrand Factor; 9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sulfonylureas in the treatment of diabetes mellitus--1985.
Next Document: Management of maternal vegetative state during pregnancy.