Document Detail


Factor VIII and von Willebrand factor changes during normal pregnancy and puerperium.
MedLine Citation:
PMID:  14517489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gestation is a challenge to haemostasis and it is associated with significant haemostatic changes. Several studies have evaluated von Willebrand factor in normal pregnancy, but none considered the personal history of bleeding. We studied a group of healthy non-bleeding women (184 pregnant, 64 puerperium, 37 non-pregnant) to evaluate normal ranges and their relationship to blood group and parity. The von Willebrand factor increased markedly from non-pregnant values up to the end of early puerperium (P < 0.0001), while factor VIII only showed a slight increase. Factor VIII and von Willebrand factor activity remained within the normal range for non-pregnant women. The return to non-pregnant factor levels occurred in late puerperium, later than previously reported. Only factor VIII was significantly lower in the O blood group (P = 0.035). As regards parity, there were no differences in factor VIII, von Willebrand factor antigen and von Willebrand factor ristocetin cofactor between primigravidae and multigravidae for any period studied (P = 0.888, 0.999, and 0.237, respectively). Our results provide reference ranges that may help to design a study in von Willebrand factor disease in pregnancy.
Authors:
Analía Sánchez-Luceros; Susana S Meschengieser; Carlos Marchese; Roberto Votta; Patricia Casais; Adriana I Woods; María V Nadal; María J Salviú; María A Lazzari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  14     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-30     Completed Date:  2004-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  647-51     Citation Subset:  IM    
Affiliation:
National Research Council (CONICET), Buenos Aires, Argentina. sanchezluceros@hematologia.anm.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Group Antigens / blood
Cross-Sectional Studies
Factor VIII / analysis*,  standards
Female
Gestational Age
Humans
Parity
Postpartum Period / blood*
Pregnancy / blood*
Prospective Studies
von Willebrand Factor / analysis*,  standards
Chemical
Reg. No./Substance:
0/Blood Group Antigens; 0/von Willebrand Factor; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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