Document Detail

Factor VIII Deficiency Does Not Protect Against Atherosclerosis.
MedLine Citation:
PMID:  21972848     Owner:  NLM     Status:  Publisher    
Background: Hemophilia A patients have a lower cardiovascular mortality compared to the general population. Whether this protection is caused by hypocoagulability or decreased atherogenesis is unclear. Objectives: To evaluate atherosclerosis and endothelial function in hemophilia A patients with and without obesity as well as in matched unaffected controls. Methods: Fifty-one obese (body mass index (BMI) ≥30 kg/m(2) ) and 47 non-obese (BMI ≤25 kg/m(2) ) hemophilia A patients, and 42 obese and 50 matched non-obese male controls were included. Carotid and femoral intima media thickness (CIMT and FIMT) and brachial flow mediated dilatation (FMD) were measured, as markers of atherogenesis and endothelial function. Results: Overall, population age was 50 ±13 years. CIMT was increased in obese (0.77 ± 0.22 mm) compared to non-obese subjects (0.69 ± 0.16 mm), (mean Δ 0.07 mm (95%CI 0.02-0.13 mm, p= 0.008). No differences in mean CIMT and FIMT between obese hemophilia patients and obese controls were found (mean Δ 0.02 mm (95% CI -0.07-0.11, p=0.67) and 0.06 mm (95% CI -0.13-0.25, p=0.55), respectively). Thirty-five percent of the obese hemophilia patients and 29% of the obese controls had an atherosclerotic plaque (p=0.49), irrespective of the severity of hemophilia. FMD was comparable between obese hemophiliacs and obese controls (4.84%± 3.24 and 5.32%± 2.37, p=0.45). Conclusion: Hemophilia A patients with obesity, develop atherosclerosis to a similar extent as the general male population. Detection and treatment of cardiovascular risk factors in hemophilia patients is equally necessary.
S Biere-Rafi; A Tuinenburg; B W Haak; M Peters; R Huijgen; E de Groot; P Verhamme; K Peerlinck; F L J Visseren; M J H A Kruip; B A P Laros-van Gorkom; V E A Gerdes; H R Buller; R E G Schutgens; P W Kamphuisen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-5
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  -     ISSN:  1538-7836     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 International Society on Thrombosis and Haemostasis.
Department of Vascular Medicine, Academic Medical Center, Amsterdam Van Creveldkliniek/Department of Haematology, University Medical Center Utrecht, Utrecht Department of Pediatric Hematology, Emma Children's Hospital, Academic Medical Center Amsterdam Vascular Imaging, Academic Medical Center, Amsterdam, The Netherlands Department of Vascular Medicine and Haemostasis, University Hospital, Leuven, Belgium Department of Internal Medicine, University Medical Center Utrecht, Utrecht Department of Hematology, Erasmus University Medical Center, Rotterdam Department of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands.
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