Document Detail

Factor VII and extrinsic pathway inhibitor in acute coronary disease.
MedLine Citation:
PMID:  2788454     Owner:  NLM     Status:  MEDLINE    
This report describes studies on the activation of coagulation factor VII (FVII) and the inhibition of the extrinsic coagulation pathway in acute ischaemic heart disease. FVII and the inhibitor of the tissue thromboplastin-FVII complex, called extrinsic pathway inhibitor (EPI), were determined in plasma from 68 patients and compared to findings in 37 normal individuals. The mean FVII amidolytic activity, the mean FVII clotting activity, as well as the FVII clotting/FVII amidolytic ratio were not significantly different in the patient groups as compared to the controls. The fraction of FVII clotting activity that is sensitive to phospholipase C, 'the FVII-phospholipid complex', was 8% in controls, 19% (P less than 0.05) in patients with acute myocardial infarction, 15% (n.s.) in angina pectoris and 13% (n.s.) in heart failure/arrhythmia patients. The 'FVII-phospholipid complex' was highly significantly correlated to triglycerides in plasma in patients with acute myocardial infarction (r = 0.88, P less than 0.001) and angina pectoris (r = 0.89, P less than 0.001). The mean EPI levels were significantly increased in patients with acute myocardial infarction (132%), angina pectoris (134%), and heart failure (150%) as compared to the control population (110%). The FVII clotting/EPI ratio was significantly decreased both in patients with acute myocardial infarction and heart failure, whereas the FVII amidolytic/EPI ratio was significantly decreased only in the heart failure group. Apparently, in patients with acute ischaemic heart disease, a moderate increase in the procoagulant activity is accompanied by a marked increase in the anticoagulant activity of the extrinsic coagulation pathway, suggesting a balanced activation system.
P M Sandset; P A Sirnes; U Abildgaard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  72     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-25     Completed Date:  1989-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Medical Department, Aker Hospital, University of Oslo, Norway.
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MeSH Terms
Acute Disease
Angina Pectoris / blood
Antigens / analysis
Coronary Disease / blood*
Factor VII / analysis*,  antagonists & inhibitors,  immunology
Factor VIIa
Lipoproteins / analysis*
Middle Aged
Myocardial Infarction / blood
Phospholipids / blood
Thromboplastin / analysis*,  antagonists & inhibitors
Triglycerides / blood
Reg. No./Substance:
0/Antigens; 0/Lipoproteins; 0/Phospholipids; 0/Triglycerides; 0/factor VII clotting antigen; 0/lipoprotein-associated coagulation inhibitor; 9001-25-6/Factor VII; 9035-58-9/Thromboplastin; EC VIIa

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