Document Detail

Factor VII deficiency detected in pregnancy: a case report.
MedLine Citation:
PMID:  10535614     Owner:  NLM     Status:  MEDLINE    
Factor VII deficiency is a rare hereditary coagulation disorder with an incidence estimated at 1 in 500,000 individuals. In this report, we describe the 13th case in pregnancy. The diagnosis of severe factor VII deficiency (factor VII level <5%) was established at 10 weeks' gestation after initial laboratory testing showed a markedly prolonged prothrombin time and a normal activated partial thromboplastin time. There was a history of two preterm deliveries, but there was no evidence of previous bleeding manifestations. Antenatal progress of the index pregnancy was unremarkable. Prophylactic treatment with fresh frozen plasma was started at the onset of labor and the patient had a vaginal delivery of a live girl at 36 weeks' gestation. There was no postpartum hemorrhage and mother and newborn were discharged in good condition. The patient's postpartum level of factor VII remained undetectable. Two aspects are outlined: the absence of any significant increase in factor VII clotting activity during this pregnancy and the need to give replacement therapy at labor in patients with severe factor VII deficiency to decrease the risk of postpartum hemorrhage.
D E Rizk; A Castella; H Shaheen; P Deb
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of perinatology     Volume:  16     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-16     Completed Date:  1999-11-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain.
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MeSH Terms
Factor VII / therapeutic use
Factor VII Deficiency / diagnosis*
Partial Thromboplastin Time
Postpartum Hemorrhage / prevention & control
Pregnancy Complications, Hematologic / diagnosis*
Prothrombin Time
Reg. No./Substance:
9001-25-6/Factor VII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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