Document Detail


Factor V Leiden and prothrombin gene mutations in Egyptian cases with unexplained recurrent pregnancy loss.
MedLine Citation:
PMID:  21269570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Thrombophilias have been suggested as a possible cause of recurrent pregnancy loss (RPL).
OBJECTIVE: Testing for the association of factor V Leiden (FVL) and prothrombin (FII) mutations with RPL among cases from the Nile Delta region of Egypt.
SUBJECTS AND METHODS: Participants included 72 cases having a history of two or more events of unexplained RPL and 70 controls with a good obstetric history. Detection of FVL (G1691A) and FII (G20210A) mutations was carried out using PCR with sequence specific primers.
RESULTS: Cases showed a significantly higher frequency of FVL GA (OR = 21·38, P<0·0001) and FII GA (OR = 36·7, P<0·0001) genotypes. Cases with two or more risk factors had significant higher frequency of both mutant genotypes, while no significant difference could be elicited related to primary or secondary infertility, number of fetal losses, or phase of pregnancy loss.
CONCLUSION: Screening for thrombophilic mutations may help in the prevention of unexplained RPL.
Authors:
Ahmad Settin; RababAbo Alkasem; Ehab Ali; Rizk ElBaz; Abdel Megid Mashaley
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hematology (Amsterdam, Netherlands)     Volume:  16     ISSN:  1607-8454     ISO Abbreviation:  Hematology     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-07-21     Revised Date:  2011-08-26    
Medline Journal Info:
Nlm Unique ID:  9708388     Medline TA:  Hematology     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Affiliation:
Genetics Unit, Mansoura University Children Hospital, Egypt. settin60@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / genetics*
Adult
Case-Control Studies
Egypt
Factor V / genetics*
Female
Humans
Mutation*
Pregnancy
Pregnancy Complications, Hematologic / genetics*
Prothrombin / genetics*
Risk Factors
Thrombophilia / genetics*
Young Adult
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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