| Factor V Leiden is not responsible for stroke in patients with sickling disorders and is uncommon in African Americans with sickle cell disease. | |
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MedLine Citation:
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PMID: 8980255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrovascular accidents in patients with sickle cell anemia are among the most devastating complications of the disease. It has recently been demonstrated that some patients have a hypercoagulable state on the basis of the presence of an abnormal factor V molecule, factor V Leiden. We undertook this study to evaluate the presence of factor V Leiden in sickle cell patients with stroke. Eighty-two patients with either Hgb SS, Hgb SC, or Hgb S(beta+)-thalassemia comprised the study population. Of the 82 patients in the study, 19 of them had a history of stroke. In our study population, none of the stroke patients possessed the factor V Leiden mutation. One of the non-stroke patients was a heterozygote for the mutation (P = 1.00). The overall frequency of the factor V Leiden allele in our population is 0.6%. The estimated prevalence for this mutation is reportedly between 3 and 7% in Caucasian populations. We conclude that the gene frequency for factor V Leiden is less common in Africa Americans with sickle cell disease. Furthermore, factor V Leiden does not appear to be responsible for the development of stroke in sickle cell patients. |
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Authors:
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M J Kahn; C Scher; M Rozans; R K Michaels; C Leissinger; J Krause |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 54 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-01-30 Completed Date: 1997-01-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 12-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Schools of Medicine and Public Health and Tropical Medicine, Tulane University Medical Center, and the Southeastern Louisiana Sickle Cell Center, New Orleans, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Americans Anemia, Sickle Cell / blood*, genetics Blood Coagulation Disorders / complications, genetics Cerebrovascular Disorders / etiology* Child Child, Preschool Factor V / genetics, physiology* Female Gene Frequency Humans Infant Male |
| Chemical | |
Reg. No./Substance:
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0/factor V Leiden; 9001-24-5/Factor V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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