Document Detail

Factor V Leiden is not responsible for stroke in patients with sickling disorders and is uncommon in African Americans with sickle cell disease.
MedLine Citation:
PMID:  8980255     Owner:  NLM     Status:  MEDLINE    
Cerebrovascular accidents in patients with sickle cell anemia are among the most devastating complications of the disease. It has recently been demonstrated that some patients have a hypercoagulable state on the basis of the presence of an abnormal factor V molecule, factor V Leiden. We undertook this study to evaluate the presence of factor V Leiden in sickle cell patients with stroke. Eighty-two patients with either Hgb SS, Hgb SC, or Hgb S(beta+)-thalassemia comprised the study population. Of the 82 patients in the study, 19 of them had a history of stroke. In our study population, none of the stroke patients possessed the factor V Leiden mutation. One of the non-stroke patients was a heterozygote for the mutation (P = 1.00). The overall frequency of the factor V Leiden allele in our population is 0.6%. The estimated prevalence for this mutation is reportedly between 3 and 7% in Caucasian populations. We conclude that the gene frequency for factor V Leiden is less common in Africa Americans with sickle cell disease. Furthermore, factor V Leiden does not appear to be responsible for the development of stroke in sickle cell patients.
M J Kahn; C Scher; M Rozans; R K Michaels; C Leissinger; J Krause
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  54     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12-5     Citation Subset:  IM    
Department of Medicine, Schools of Medicine and Public Health and Tropical Medicine, Tulane University Medical Center, and the Southeastern Louisiana Sickle Cell Center, New Orleans, USA.
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MeSH Terms
African Americans
Anemia, Sickle Cell / blood*,  genetics
Blood Coagulation Disorders / complications,  genetics
Cerebrovascular Disorders / etiology*
Child, Preschool
Factor V / genetics,  physiology*
Gene Frequency
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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