Document Detail

Factor V Leiden mutation in cerebral venous thrombosis.
MedLine Citation:
PMID:  8841317     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Resistance to activated protein C is a common inherited risk factor for venous thrombosis, which is due to a mutation in coagulation factor V (factor V Leiden mutation). It is present in approximately 20% of unselected consecutive patients with deep vein thrombosis. The rate of resistance to activated protein C in patients with cerebral venous thrombosis (CVT) is unknown. METHODS: We investigated the association of factor V mutation with CVT using a case-control study. Nineteen unselected patients with CVT and 57 healthy control subjects were tested for the point mutation. RESULTS: The mutation was found in a heterozygous form in 4 of the 19 patients with CVT (21%) and in only 1 of the 57 control subjects (2%) (P = .02, Fisher's exact test). The prevalence of the coagulation defect found in our patients with CVT was consistent with that observed in previous studies in patients with deep vein thrombosis. In 3 of the 4 patients positive for the mutation, CVT developed in the presence of an acquired prothrombotic state, including oral contraceptive use in 2 patients and puerperium in the third. CONCLUSIONS: Factor V Leiden mutation is a risk factor for CVT and may be the most common inherited coagulation defect associated with this condition.
M Zuber; P Toulon; L Marnet; J L Mas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  27     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-15     Completed Date:  1996-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1721-3     Citation Subset:  IM    
Service de Neurologie, Centre R. Garcin, Hôpital Sainte-Anne, Paris, France.
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MeSH Terms
Case-Control Studies
Cerebral Veins
Contraceptives, Oral / adverse effects
Factor V / genetics*
Intracranial Embolism and Thrombosis / genetics*
Middle Aged
Puerperal Disorders / genetics
Risk Factors
Reg. No./Substance:
0/Contraceptives, Oral; 0/factor V Leiden; 9001-24-5/Factor V
Comment In:
Stroke. 1996 Oct;27(10):1719-20   [PMID:  8841316 ]

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