Document Detail

Factor V Leiden mutation in pregnancy.
MedLine Citation:
PMID:  15180198     Owner:  NLM     Status:  MEDLINE    
Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of the White and 1% of the Black populations. Nurses should be knowledgeable about screening for and diagnosis of factor V Leiden mutation, risk reduction counseling, recommended care of the affected patient, and implications of anticoagulant therapy during the perinatal period.
Susan Murphy Cohen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG     Volume:  33     ISSN:  0884-2175     ISO Abbreviation:  J Obstet Gynecol Neonatal Nurs     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-06-07     Completed Date:  2004-07-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8503123     Medline TA:  J Obstet Gynecol Neonatal Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM; N    
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MeSH Terms
Activated Protein C Resistance* / genetics,  nursing
Anticoagulants / therapeutic use
Factor V* / genetics
Fetal Growth Retardation / genetics,  prevention & control
Nursing Methodology Research
Obstetrical Nursing / standards
Patient Education as Topic / methods
Point Mutation*
Pregnancy Complications, Cardiovascular* / nursing
Pregnancy Complications, Hematologic* / nursing
Pregnancy Outcome
Risk Factors
Thromboembolism / genetics,  nursing
Venous Thrombosis* / genetics,  nursing
Reg. No./Substance:
0/Anticoagulants; 0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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