Document Detail

Factor V Leiden: a case study and review.
MedLine Citation:
PMID:  20010186     Owner:  NLM     Status:  MEDLINE    
Venous thromboembolism accounts for approximately 600,000 hospitalizations and 50,000 deaths per year in the United States. Many inherited blood disorders predispose patients to this disorder. The most common of these disorders is factor V Leiden. Factor V Leiden thrombophilia is an inherited disorder, mutation, of the mechanisms of blood clotting. The mutation causes resistance to activated protein C and thus causes a defect in the natural anticoagulation system. This predisposes patients to recurrent deep vein thrombosis and in combination with other risk factors can cause significant morbidity. This article discusses the pathophysiology, disease characteristics, risk factors for venous thromboembolism, diagnosis and testing, management of factor V Leiden, and implications for nursing in regard to factor V Leiden. The frequency of factor V Leiden and its prevalence in thromboembolic disease emphasize the need for nursing professionals from many diverse backgrounds to better understand the consequences of the factor V Leiden mutation.
Kimberlee B Slusher
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Dimensions of critical care nursing : DCCN     Volume:  29     ISSN:  1538-8646     ISO Abbreviation:  Dimens Crit Care Nurs     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211489     Medline TA:  Dimens Crit Care Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  N    
The Jewish Hospital, Blood and Marrow Transplant Unit, Cincinnati, Ohio, USA.
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MeSH Terms
Blood Coagulation Factors / genetics
Factor V / genetics*
Intracranial Aneurysm / surgery
Neurosurgical Procedures
Point Mutation / genetics
Receptors, Cell Surface / genetics
Risk Factors
Venous Thromboembolism* / diagnosis,  genetics,  physiopathology
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Receptors, Cell Surface; 0/activated protein C receptor; 0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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