Document Detail

Factor V (Arg 506-->Gln) mutation in young survivors of myocardial infarction.
MedLine Citation:
PMID:  8725707     Owner:  NLM     Status:  MEDLINE    
Many young patients with venous thromboembolic disease are partially resistant to the anticoagulant action of activated protein C as a result of factor V (Arg 506 --> Gln) mutation. The frequency of this mutation in young patients with arterial thrombotic diseases, such as myocardial infarction, is less well established. We studied 100 young patients with myocardial infarction and 100 age- and sex-matched controls. One patient (1%; 95% CL 0.05-6.2) and two controls (2%; 95% CL 0.3-7.7) were heterozygotes for the mutation; there was no homozygote in either group. Hence, premature myocardial infarction is not associated with heterozygosity for factor V (Arg 506 --> Gln) mutation.
D Ardissino; F Peyvandi; P A Merlini; E Colombi; P M Mannucci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  75     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  701-2     Citation Subset:  IM    
Division of Cardiology, I.R.C.C.S., Policlinico San Matteo, Pavia, Italy.
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MeSH Terms
Age Factors
Arginine / genetics
Case-Control Studies
Factor V / genetics*
Myocardial Infarction / blood,  genetics*
Point Mutation
Reg. No./Substance:
74-79-3/Arginine; 9001-24-5/Factor V

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