Document Detail

Factor IX and thrombosis.
MedLine Citation:
PMID:  267296     Owner:  NLM     Status:  MEDLINE    
Fractionation technology has made Factor IX concentrates available. In addition to a very high incidence of hepatitis, thrombosis is being recognized as a consequence of their use. Contradictory reports exist in the literature as to the incidence of thrombotic events. A recent study of thrombohemorrhagic phenomena after infusion with Factor IX concentrates in patients with congenital Factor IX deficiency (hemophilia B) or liver disease, revealed an incidence of twenty episodes in 188 cases (11%). It is imperative to delineate the thrombogenic factors and find methods for their removal to insure the safety of Factor IX products.
L M Aledort
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of haematology. Supplementum     Volume:  30     ISSN:  0080-6722     ISO Abbreviation:  Scand J Haematol Suppl     Publication Date:  1977  
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0104315     Medline TA:  Scand J Haematol Suppl     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  40-2     Citation Subset:  IM    
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MeSH Terms
Factor IX / adverse effects*,  therapeutic use
Hemophilia B / therapy
Hemorrhage / chemically induced
Thrombosis / chemically induced*
Reg. No./Substance:
9001-28-9/Factor IX

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