| Facilitation of neonatal nasotracheal intubation with premedication: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 12030995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine if premedication reduces the time and number of attempts by junior medical staff to achieve nasotracheal intubation in neonates. The experimental design was a non-blinded randomized controlled pilot trial. The setting was a perinatal centre in a university teaching hospital. METHODS: Twenty infants (within the ranges of 25-40 weeks gestation, 650-3660 g and 1 h to 81 days of age) requiring semi-urgent intubation were randomized to either premedication with morphine, atropine and suxamethonium, or to awake intubation. RESULTS: There were no significant differences between the two groups in regard to prior intubation experience of the staff or infant weight or gestation. The intubation procedure, including intervening events, to completion was significantly faster in premedicated infants (median 60 s vs 595 s; P = 0.002) who were intubated at a younger postnatal age. It took twice as many attempts to intubate a conscious infant (median 2 vs 1; P = 0.010). There was a greater decrease in heart rate from the baseline in the unpremedicated group (mean 68 b.p.m. vs 29 b.p.m.; P = 0.017), but decreases in oxygen saturation were not different. Blood was observed in the oral and nasal passages after intubation in five of the awake infants and in one of the premedicated infants. CONCLUSIONS: The use of premedication reduces the total time and number of attempts taken to achieve successful nasotracheal intubation of neonates by junior medical staff under supervision. |
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Authors:
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J Oei; R Hari; T Butha; K Lui |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of paediatrics and child health Volume: 38 ISSN: 1034-4810 ISO Abbreviation: J Paediatr Child Health Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-05-28 Completed Date: 2002-06-13 Revised Date: 2007-09-24 |
Medline Journal Info:
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Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: Australia |
Other Details:
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Languages: eng Pagination: 146-50 Citation Subset: IM |
Affiliation:
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Department of Newborn Care, Royal Hospital for Women, Randwick, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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administration & dosage Atropine / administration & dosage Australia Heart Rate Humans Infant Infant, Newborn Intensive Care, Neonatal / methods*, standards Intubation, Intratracheal / methods*, standards Morphine / administration & dosage Neuromuscular Depolarizing Agents / administration & dosage Nose Oxygen / blood Parasympatholytics / administration & dosage Pilot Projects Premedication* / utilization Succinylcholine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Neuromuscular Depolarizing Agents; 0/Parasympatholytics; 306-40-1/Succinylcholine; 51-55-8/Atropine; 57-27-2/Morphine; 7782-44-7/Oxygen |
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