Document Detail


Facilitation of monosynaptic and complex PSPs in type I interneurons of conditioned Hermissenda.
MedLine Citation:
PMID:  12196605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synaptic plasticity and intrinsic changes in neuronal excitability are two mechanisms for Pavlovian conditioning. Pavlovian conditioning of Hermissenda produces synaptic facilitation of monosynaptic medial B-medial A IPSPs and intrinsic changes in excitability of type A and B cells in isolated and intact sensory neurons of the conditioned stimulus (CS) pathway. Recently two types of interneurons that receive either excitatory or inhibitory monosynaptic or polysynaptic input from photoreceptors have been identified. On the basis of morphological and electrophysiological criteria, the interneurons have been classified as type I(e), I(i) (direct), and type II(e), II(i) (indirect). We have now examined synaptic facilitation of monosynaptic PSPs in type I(e) and I(i) interneurons after conditioning and pseudorandom control procedures. Here we report that CS-elicited spike activity is increased in type I(e) interneurons and decreased in type I(i) interneurons of conditioned animals relative to their respective baseline activity and pseudorandom control groups. Classical conditioning resulted in synaptic facilitation of type I(e) and I(i) monosynaptic PSPs elicited by lateral B spikes and enhancement of the amplitude of complex PSPs elicited by the CS. These results provide additional sites of plasticity in the neural circuit involved with the expression of learned behavior produced by Pavlovian conditioning of Hermissenda.
Authors:
Terry Crow; Lian-Ming Tian
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  22     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-27     Completed Date:  2002-09-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7818-24     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA. terry.crow@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Association Learning / physiology
Behavior, Animal / physiology
Conditioning, Classical / physiology*
Excitatory Postsynaptic Potentials / physiology*
Interneurons / classification,  physiology*
Mollusca
Neuronal Plasticity / physiology*
Photoreceptor Cells, Invertebrate / physiology
Synapses / physiology*
Grant Support
ID/Acronym/Agency:
MH-58698/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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