Document Detail

Facilitation of lordosis in rats by a metabolite of luteinizing hormone releasing hormone.
MedLine Citation:
PMID:  16497796     Owner:  NLM     Status:  MEDLINE    
In the female rat, ovulation is preceded by a marked increase in the release of the decapeptide, LHRH, culminating in a preovulatory LH surge, which coincides with a period of sexual receptivity. The decapeptide, LHRH, is processed by a zinc metalloendopeptidase EC (EP24.15) that cleaves the hormone at the Tyr(5)-Gly(6) bond. We have previously reported that the autoregulation of LHRH gene expression can also be mediated by its metabolite, LHRH-(1-5). Given the central function of LHRH in reproduction and reproductive behavior, we examined the role of the metabolite, LHRH-(1-5), in mediation of LHRH-facilitated reproductive behavior. Intracerebroventricular administration of LHRH-(1-5) facilitated sexual behavior responses, similar to those facilitated by the decapeptide LHRH, in ovariectomized estradiol-primed female rats. Furthermore, immunoneutralization of EP24.15 resulted in the inhibition of the LHRH-facilitated lordosis but had no inhibitory effects on LHRH-(1-5)-facilitated lordosis. The LHRH antagonist, Antide, was capable of inhibiting LHRH-facilitated lordosis, without affecting LHRH-(1-5)-facilitated lordosis. Collectively, these results suggest a role for LHRH metabolites in the facilitation of female receptive behavior in rats.
T J Wu; Marc J Glucksman; James L Roberts; Shaila K Mani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-02-23
Journal Detail:
Title:  Endocrinology     Volume:  147     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-05-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2544-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.
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MeSH Terms
Analysis of Variance
Behavior, Animal
Estradiol / metabolism
Gene Expression Regulation
Gonadotropin-Releasing Hormone / metabolism*
Luteinizing Hormone / metabolism
Nervous System Physiological Phenomena
Neurons / metabolism
Oligopeptides / pharmacology
Peptides / chemistry
Rats, Sprague-Dawley
Sexual Behavior, Animal*
Grant Support
Reg. No./Substance:
0/Oligopeptides; 0/Peptides; 112568-12-4/iturelix; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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