| Facilitation in ON-OFF directionally selective ganglion cells of the rabbit retina. | |
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MedLine Citation:
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PMID: 8350138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. We have investigated the facilitation of extracellularly recorded responses of ON-OFF directionally selective (DS) ganglion cells of the rabbit retina to two-slit preferred-direction apparent motion produced by both prolonged light steps, which simulate movement of an edge past two apertures, and light flashes, which simulate movement of a spot or slit. 2. Within the excitatory receptive-field center of DS ganglion cells, apparent motion with prolonged light steps elicits preferred-direction facilitation whose rise time (220 +/- 150 ms, average rise to 90% of maximum for 6 cells) is typically longer than the rise time of the excitatory response elicited by each slit. The decay time to baseline of facilitation during prolonged light steps is generally longer than 500 ms and hence greatly exceeds the typical duration of the excitatory response elicited by the slits. 3. Prolonged light steps are generally effective for facilitating any given excitatory receptive-field locus from a roughly ovoid area that typically extends on the order of 100-200 microns in the preferred direction, which is less than one-half the size of the excitatory receptive-field center. Within 100 microns, facilitation can occur for motion diagonal to the preferred-null axis as long as the projection of the motion on the preferred-null axis points in the preferred direction. 4. The time course of preferred-direction facilitation between two slits does not appear to have a strong systematical dependence on the interslit distance over the range in which facilitation is effective. 5. Short light flashes are ineffective for eliciting facilitation and, at sufficiently long interslit delays, elicit inhibition all around the test slit. This inhibition may be due to the antagonistic surround mechanism within the receptive-field center, which is effectively elicited by short-duration stimuli. 6. The effect of preferred-direction facilitation is addition-like, rather than multiplication-like. That is, the facilitatory effect of the first slit appears as the addition of a fixed value to the response-versus-contrast curve of the second slit, rather than a multiplication of the curve by a constant factor. The functional relationship between strength of facilitation and contrast of the first slit is sigmoidal, however, and thus nonlinear. 7. Experiments with long light steps show that the interaction between excitation and preferred-direction facilitation is largely segregated between the ON and OFF pathways.(ABSTRACT TRUNCATED AT 400 WORDS) |
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Authors:
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N M Grzywacz; F R Amthor |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurophysiology Volume: 69 ISSN: 0022-3077 ISO Abbreviation: J. Neurophysiol. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-09-14 Completed Date: 1993-09-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2188-99 Citation Subset: IM |
Affiliation:
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Smith-Kettlewell Eye Research Institute, San Francisco, California 94115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Male Models, Neurological Motion Perception / physiology Photic Stimulation Rabbits Retinal Ganglion Cells / physiology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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EY-03039/EY/NEI NIH HHS; EY-05070/EY/NEI NIH HHS; EY-08921/EY/NEI NIH HHS |
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