| Facilitation of gastric compliance and cardiovascular reaction by repeated isobaric distension of the rat stomach. | |
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MedLine Citation:
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PMID: 15916627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric distension causes cardiovascular reactions and enhances gastric compliance. Here, we investigated how these responses are related to each other, whether they change upon repeated distension and which neural mechanisms are involved. Mean arterial blood pressure (MAP) in phenobarbital-anaesthetized rats was recorded from a carotid artery and gastric compliance determined with an electronic barostat. Runs of intermittent gastric distension were generated by stepwise increments (5 mmHg) of intragastric (IG) pressure. While gastric compliance peaked at IG pressures of 20 mmHg, the change in MAP (predominantly hypotension) was largest at IG pressures beyond 30 mmHg. Repeated distension enhanced the MAP response to IG pressures beyond 35 mmHg, whereas gastric compliance was facilitated primarily at IG pressures below 20 mmHg. This facilitation of gastric compliance depended on the magnitude of the preceding distension. The MAP response to distension was enhanced by nitric oxide synthase inhibition, inhibited by subdiaphragmatic vagotomy but hardly affected by coeliac ganglionectomy. The facilitation of gastric compliance was changed by vagotomy in a complex manner but left unaltered by the other interventions. These findings show that isobaric gastric distension elicits both MAP and gastric compliance responses whose characteristics, mechanisms and sensitization properties differ profoundly. |
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Authors:
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M Römer; E Painsipp; I Schwetz; P Holzer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 17 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-26 Completed Date: 2005-06-27 Revised Date: 2011-04-06 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 399-409 Citation Subset: IM |
Affiliation:
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Department of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pressure Animals Blood Pressure / physiology Compliance Denervation Enzyme Inhibitors / pharmacology Female Ganglia, Sympathetic / physiology Gastric Acid / physiology Hemodynamics / physiology* Manometry NG-Nitroarginine Methyl Ester / pharmacology Neural Pathways / physiology Nitric Oxide / physiology Nitric Oxide Synthase / antagonists & inhibitors Physical Stimulation Rats Rats, Sprague-Dawley Stomach / innervation, physiology* Stress, Mechanical Vagotomy |
| Grant Support | |
ID/Acronym/Agency:
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L 25-B05//Austrian Science Fund FWF |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 1.14.13.39/Nitric Oxide Synthase |
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