Document Detail

Facilitation of ejaculation induced by 8-OH-DPAT does not produce conditioned place preference in male rats.
MedLine Citation:
PMID:  17592949     Owner:  NLM     Status:  MEDLINE    
The serotonin 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) produces a drastic facilitation of ejaculation characterized by a significant reduction in the number of pre-ejaculatory intromissions and a shortening of ejaculation latency. In the present study, the authors evaluated whether this facilitation of ejaculation can induce a reward state assessed by conditioned place preference. Males treated with 0.1 or 1.0 mg/kg of 8-OH-DPAT showed a clear facilitation of ejaculation but did not develop conditioned place preference. These results clearly indicate that the pharmacological facilitation of ejaculation and the reduction of the number of intromissions does not necessarily make sex rewarding.
Francisco J Camacho; María Castro; Valeria Hernández; Raúl G Paredes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  121     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-26     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-85     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 APA, all rights reserved.
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México.
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MeSH Terms
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology*
Behavior, Animal / drug effects
Conditioning, Operant / drug effects*
Copulation / drug effects
Dose-Response Relationship, Drug
Ejaculation / drug effects*
Rats, Wistar
Reproducibility of Results
Serotonin Agonists / pharmacology*
Reg. No./Substance:
0/Serotonin Agonists; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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