Document Detail

Facilitation of ECT by intravenous administration of theophylline.
MedLine Citation:
PMID:  9034698     Owner:  NLM     Status:  MEDLINE    
Seven patients with major depression who developed seizure inhibition during a course of ECT, were given intravenous theophylline to increase seizure duration. Infusion of 100-200 mg of theophylline, administered slowly over several minutes approximately 30 min before seizure induction, was found to effectively and safely prolong seizure durations. In a total of 55 treatment sessions, no cardiovascular or other complications were seen. On one occasion, seizure duration was prolonged to 220 s.
A F Leentjens; W W van den Broek; A Kusuma; J A Bruijn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Convulsive therapy     Volume:  12     ISSN:  0749-8055     ISO Abbreviation:  Convuls Ther     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-05-20     Completed Date:  1997-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8506311     Medline TA:  Convuls Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  IM    
Department of Psychiatry, University Hospital Rotterdam, Dijkzigt, The Netherlands.
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MeSH Terms
Depressive Disorder / psychology,  therapy*
Dose-Response Relationship, Drug
Drug Administration Schedule
Electroconvulsive Therapy / methods*
Electroencephalography / drug effects*
Evoked Potentials / drug effects
Infusions, Intravenous
Middle Aged
Psychotic Disorders / psychology,  therapy*
Receptors, Purinergic P1 / antagonists & inhibitors*
Theophylline / administration & dosage*
Reg. No./Substance:
0/Receptors, Purinergic P1; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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