Document Detail

Facile one-pot synthesis of N-acyl-1H-1,2,3-benzotriazoles from internal and terminal olefinic fatty acids and their antimicrobial screening.
MedLine Citation:
PMID:  18622129     Owner:  NLM     Status:  MEDLINE    
N-acyl-1H-1,2,3-benzotriazoles were prepared in good yields by the reaction of benzotriazole and thionyl chloride with olefinic fatty acids under mild reaction conditions. The new compounds 1-(undec-10-enoyl)-1H-1,2,3-benzotriazole (5a),1-[(Z)-octadec-9-enoyl]-1H-1,2,3-benzotriazole (5b), 1-[(9Z,12R)-12-hydroxyoctadec-9-enoyl]-1H-1,2,3-benzotriazole (5c), 1-[(9R,12Z)-9-hydroxyoctadec-12-enoyl]-1H-1,2,3-benzotriazole (5d) formed were characterized on the basis of elemental analysis and spectral data. All the newly synthesized compounds (5a-5d) were screened for their antimicrobial activity and showed good antifungal activity.
Abdul Rauf; Saloni Gangal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oleo science     Volume:  57     ISSN:  1347-3352     ISO Abbreviation:  J Oleo Sci     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-09-08     Revised Date:  2009-08-11    
Medline Journal Info:
Nlm Unique ID:  101175339     Medline TA:  J Oleo Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  453-7     Citation Subset:  IM    
Department of Chemistry, Aligarh Muslim University, Aligarh, India. <>
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MeSH Terms
Anti-Infective Agents / chemical synthesis,  pharmacology*
Bacteria / drug effects*
Fatty Acids, Unsaturated / chemistry*
Fungi / drug effects*
Microbial Sensitivity Tests
Structure-Activity Relationship
Sulfur Oxides / chemistry*
Triazoles / chemical synthesis*,  pharmacology*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Fatty Acids, Unsaturated; 0/Sulfur Oxides; 0/Triazoles; 7719-09-7/thionyl chloride

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