| A Facile Synthesis, <i>in vitro</i> and <i>in vivo</i> MR Studies of D-Glucuronic Acid Coated Ultrasmall Ln<sub>2</sub>O<sub>3</sub> (Ln = Eu, Gd, Dy, Ho, and Er) Nanoparticles as a New Potential MRI Contrast Agent. | |
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MedLine Citation:
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PMID: 21853997 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A facile one-pot synthesis of D-glucuronic acid coated ultrasmall Ln<sub>2</sub>O<sub>3</sub> (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the D-glucuronic acid coated ultrasmall Dy<sub>2</sub>O<sub>3</sub> nanoparticle because it showed the highest <i>r</i><sub>2</sub> relaxivity among studied nanoparticles. Its performance as a <i>T</i><sub>2</sub> MRI contrast agent was for the first time proved <i>in vivo</i> through its 3 Tesla <i>T</i><sub>2</sub> MR images of a mouse, showing that it can be further exploited for the rational design of a new <i>T</i><sub>2</sub> MRI contrast agent at high MR fields. |
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Authors:
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Krishna Kattel; Ja Young Park; Wenlong Xu; Han Gyeol Kim; Eun Jung Lee; Badrul Alam Bony; Woo Choul Heo; Jae Jun Lee; Seonguk Jin; Jong Su Baeck; Yongmin Chang; Tae-Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: ACS applied materials & interfaces Volume: - ISSN: 1944-8252 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504991 Medline TA: ACS Appl Mater Interfaces Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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