Document Detail

Facile syntheses of enantiopure 3-hydroxypiperidine derivatives and 3-hydroxypipecolic acids.
MedLine Citation:
PMID:  20136156     Owner:  NLM     Status:  MEDLINE    
Facile syntheses of enantiopure trans- and cis-3-hydroxypiperidine derivatives and 3-hydroxypipecolic acids are reported, featuring Rh-catalyzed cyclohydrocarbonylation through common intermediates. A diaxial conformation in a 2,3-disubstituted N-Boc-piperidinyl structure is revealed by an X-ray crystallographic analysis.
Wen-Hua Chiou; Gau-Hong Lin; Chih-Wei Liang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  75     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1748-51     Citation Subset:  IM    
Department of Chemistry, National Chung Hsing University, Taichung, Taiwan, R.O.C.
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MeSH Terms
Crystallography, X-Ray
Models, Molecular
Molecular Conformation
Molecular Structure
Picolinic Acids / chemical synthesis*,  chemistry
Piperidines / chemical synthesis*,  chemistry
Reg. No./Substance:
0/Picolinic Acids; 0/Piperidines; 874-24-8/3-hydroxypicolinic acid

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