Document Detail


A Facile Route to Boronic Acid Functional Polymeric Microspheres via Epoxide Ring Opening.
MedLine Citation:
PMID:  22539047     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Boronic acid-functionalized microspheres are prepared for the first time via mild epoxide ring opening based on porous cross-linked polymeric microspheres (diameter ≈ 10 μm, porosity ≈ 1000 Å). Quantitative chemical analysis by XPS and EA evidences that there is a greater functionalization with boronic acid when employing a sequential synthetic method [1.7 atom% boron (XPS); 1.12 wt% nitrogen (EA)] versus a one-pot synthetic method [0.2 atom% boron (XPS); 0.60 wt% nitrogen (EA)] yielding grafting densities ranging from approximately 2.5 molecules of boronic acid per nm(2) to 1 molecule of boronic acid per nm(2) , respectively. Furthermore, the boronic acid-functionalized microspheres are conjugated with a novel fluorescent glucose molecule demonstrating a homogeneous spatial distribution of boronic acid.
Authors:
Andrew P Vogt; Vanessa Trouillet; Alexandra M Greiner; Michael Kaupp; Udo Geckle; Leonie Barner; Thorsten Hofe; Christopher Barner-Kowollik
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  Macromolecular rapid communications     Volume:  -     ISSN:  1521-3927     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9888239     Medline TA:  Macromol Rapid Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology, Engesserstraße 18, 76128 Karlsruhe, Germany.
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