| Facile preparation of oxazole-4-carboxylates and 4-ketones from aldehydes using 3-oxazoline-4-carboxylates as intermediates. | |
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MedLine Citation:
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PMID: 20608663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel 2-step synthesis of oxazole-4-carboxylates from aldehydes was developed, which is characterized by the utilization of 3-oxazoline-4-carboxylates as synthetic intermediates. The facile preparation of 4-keto-oxazole derivatives from 3-oxazoline-4-carboxylates based on their interesting reactivity toward Grignard reagents is also described. |
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Authors:
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Kenichi Murai; Yusuke Takahara; Tomoyo Matsushita; Hideyuki Komatsu; Hiromichi Fujioka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Organic letters Volume: 12 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 3456-9 Citation Subset: IM |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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chemistry* Carboxylic Acids / chemical synthesis*, chemistry Combinatorial Chemistry Techniques Indicators and Reagents Ketones / chemical synthesis*, chemistry Molecular Structure Oxazoles / chemical synthesis*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Carboxylic Acids; 0/Indicators and Reagents; 0/Ketones; 0/Oxazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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