Document Detail


Facile Fabrication of "Dual Click" One- and Two-Dimensional Orthogonal Peptide Concentration Gradients.
MedLine Citation:
PMID:  23330789     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Peptides, proteins and extracellular matrix act synergistically to influence cellular function at the biotic-synthetic interface. However identifying the individual and cooperative contributions of the various combinations and concentration regimes is extremely difficult. The confined channel deposition method we describe affords highly tunable orthogonal reactive concentration gradients that greatly expand the dynamic range, spatial control, and chemical versatility of the reactive silanes that can be controllably deposited. Using metal-free "dual click" immobilization chemistries, multiple peptides with a variety of functionality can be immobilized efficiently and reproducibly enabling optimal concentration profiling and the assessment of synergistic interactions.
Authors:
Yanrui Ma; Jukuan Zheng; Emily F Amond; Christopher M Stafford; Matthew L Becker
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Biomacromolecules     Volume:  -     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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