| A Facile Cu(I)/TF-BiphamPhos-Catalyzed Asymmetric Approach to Unnatural alpha-Amino Acid Derivatives Containing gem-Bisphosphonates (BP). | |
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MedLine Citation:
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PMID: 21707068 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A novel catalytic asymmetric Michael addition of azomethine ylide with beta-substituted alkylidene bisphosphates was realized in the presence of a chiral Copper(I)/TF-BiphamPhos complex. The present system provides a unique and facile access to enantioenriched alpha-unnatural amino acid derivatives containing gem-bisphos-phonates (BP) in high yields and excellent diastereoselectivities and enantioselectivities. Subsequent transformations led to expedient preparation of biologically active alpha-unnatural amino acid derivatives containing bisphosphonates and bisphosphonic acids without loss of diastereo- and enantiomeric excess. |
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Authors:
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Zhi-Yong Xue; Qing-Hua Li; Hai-Yan Tao; Chun-Jiang Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-27 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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