Document Detail


A Facile Cu(I)/TF-BiphamPhos-Catalyzed Asymmetric Approach to Unnatural alpha-Amino Acid Derivatives Containing gem-Bisphosphonates (BP).
MedLine Citation:
PMID:  21707068     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A novel catalytic asymmetric Michael addition of azomethine ylide with beta-substituted alkylidene bisphosphates was realized in the presence of a chiral Copper(I)/TF-BiphamPhos complex. The present system provides a unique and facile access to enantioenriched alpha-unnatural amino acid derivatives containing gem-bisphos-phonates (BP) in high yields and excellent diastereoselectivities and enantioselectivities. Subsequent transformations led to expedient preparation of biologically active alpha-unnatural amino acid derivatives containing bisphosphonates and bisphosphonic acids without loss of diastereo- and enantiomeric excess.
Authors:
Zhi-Yong Xue; Qing-Hua Li; Hai-Yan Tao; Chun-Jiang Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-27
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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