Document Detail

Facial growth in patients with Apert and Crouzon syndromes compared to normal children.
MedLine Citation:
PMID:  21214324     Owner:  NLM     Status:  Publisher    
Abstract Objective: To evaluate vertical and sagittal facial growth of children with the syndromes of Apert and Crouzon compared to the growth pattern of a non-syndromic control group. Design: Case-control study. Setting: Department of Orthodontics, Children's Hospital Erasmus MC, Sophia, Rotterdam, The Netherlands. Patients, Participants: 62 patients (37 patients with Crouzon syndrome and 25 patients with Apert syndrome) born between 1971 and 2001 (age range 3.9 - 32 years). Interventions: Lateral cephalograms performed prior to any midfacial surgery of 62 patients and 482 non-syndromic children were traced and horizontal and vertical measurements were digitized. Main Outcome Measure(s): Cephalometric measurements of SNA, SNB, ANB, NSMe, SN/PP angle, and LFH ratio. Results: Horizontal measurements for the syndromic groups showed no change in SNA angle during growth. SNA angles were lower in patients with Apert syndrome compared to patients with Crouzon syndrome. The syndromic groups showed smaller values for ANB angles compared to the non-syndromic group. Vertical measurements showed increased LFH ratios for the syndromic groups compared to control subjects. There was an increasing counterclockwise rotation of the palatal plane in relation to the anterior cranial base in syndromic patients. NSMe angles between the three groups were not significantly different. Conclusions: Based on the growth differences identified, the sagittal and vertical jaw relationships differ in patients with Crouzon syndrome, patients with Apert syndrome, and in control subjects. The syndromic patients show aggravation in midfacial underdevelopment and an anterior rotation of the mandible. Key Words: Apert and Crouzon patients, horizontal and vertical craniofacial growth.
Jacobus Reitsma; Edwin Ongkosuwito; Peter Buschang; Birte Prahl-Andersen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-23
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  -     ISSN:  1545-1569     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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