Document Detail


Facial emotion recognition impairment in chronic temporal lobe epilepsy.
MedLine Citation:
PMID:  19175397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate facial emotion recognition (FER) in a cohort of 176 patients with chronic temporal lobe epilepsy (TLE). METHODS: FER was tested by matching facial expressions with the verbal labels for the following basic emotions: happiness, sadness, fear, disgust, and anger. Emotion recognition performances were analyzed in medial (n = 140) and lateral (n = 36) TLE groups. Fifty healthy subjects served as controls. The clinical and neuroradiologic variables potentially affecting the ability to recognize facial expressions were taken into account. RESULTS: The medial TLE (MTLE) group showed impaired FER (86% correct recognition) compared to both the lateral TLE patients (FER = 93.5%) and the controls (FER = 96.4%), with 42% of MTLE patients recording rates of FER that were lower [by at least 2 standard deviations (SDs)] than the control mean. The MTLE group was impaired compared to the healthy controls in the recognition of all basic facial expressions except happiness. The patients with bilateral MTLE were the most severely impaired, followed by the right and then the left MTLE patients. FER was not affected by type of lesion, number of antiepileptic drugs (AEDs), aura semiology, or gender. Conversely, the early onset of seizures/epilepsy was related to FER deficits. These deficits were already established in young adulthood, with no evidence of progression in older MTLE patients. CONCLUSION: These results on a large cohort of TLE patients demonstrate that emotion recognition deficits are common in MTLE patients and widespread across negative emotions. We confirm that early onset seizures with right or bilateral medial temporal dysfunction lead to severe deficits in recognizing facial expressions of emotions.
Authors:
Stefano Meletti; Francesca Benuzzi; Gaetano Cantalupo; Guido Rubboli; Carlo Alberto Tassinari; Paolo Nichelli
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Publication Detail:
Type:  Journal Article     Date:  2009-01-21
Journal Detail:
Title:  Epilepsia     Volume:  50     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1547-59     Citation Subset:  IM    
Affiliation:
Department of Neurosciences, Nuovo Ospedale Civile S Agostino-Estense, University of Modena and Reggio Emilia, Modena, Italy. giuseppe.capovilla@ospedalimantova.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Anticonvulsants / pharmacology,  therapeutic use
Chronic Disease
Discrimination (Psychology)
Emotions / drug effects,  physiology*
Epilepsy, Temporal Lobe / classification,  complications*,  drug therapy,  psychology*
Facial Expression*
Female
Functional Laterality
Humans
Male
Memory Disorders / etiology*
Middle Aged
Neuropsychological Tests
Pattern Recognition, Visual / drug effects,  physiology
Retrospective Studies
Statistics as Topic
Young Adult
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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