Document Detail


Face sensorimotor cortex neuroplasticity associated with intraoral alterations.
MedLine Citation:
PMID:  21333807     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Loss of teeth or dental attrition is a common clinical occurrence associated with altered somatosensation and impaired oral motor behavior (e.g., mastication, deglutition, phonation). Oral rehabilitation aims at restoring these sensorimotor functions to improve patients' quality of life. Recent studies have implicated neuroplastic changes within the primary motor cortex (M1) in the control of limb motor behaviors following manipulations of sensory inputs to or motor outputs from the central nervous system as well as in learning and adaptation processes. However, limited data are available of the neuroplastic capabilities of face-M1 in relation to orofacial motor functions. The overall objective of our series of studies was to use intracortical microstimulation (ICMS) and recordings of evoked muscle electromyographic activity to test if neuroplastic changes occur in the ICMS-defined motor representations of the tongue-protrusive (genioglossus, GG) and jaw-opening (anterior digastric, AD) muscles within the rat face-M1 and adjacent face primary somatosensory cortex (face-S1) following several different types of intraoral manipulations. We found that a change in diet consistency was not associated with statistically significant changes in AD and GG motor representations. However, incisor extraction resulted, one week later, in a significantly increased AD representation within the contralateral face-M1 and face-S1, and incisor trimming produced time-dependent changes in the AD motor representation. These novel findings underscore the neuroplastic capabilities of the face sensorimotor cortex and point to its possible role in adaptation to an altered peripheral state or altered sensorimotor behavior. Further insights into the neuroplastic capabilities of the face sensorimotor cortex promise to improve therapeutic strategies aimed at the restoration of oral functions, particularly in patients suffering from orofacial sensorimotor deficits or pain.
Authors:
Limor Avivi-Arber; Jye-Chang Lee; Barry J Sessle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in brain research     Volume:  188     ISSN:  1875-7855     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  135-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Department of Prosthodontics, Faculty of Dentistry, University of Toronto, Ontario, Canada.
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