Document Detail


Fabrication of quantum dot-conjugated collagen/hyaluronic Acid porous scaffold.
MedLine Citation:
PMID:  23154339     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT: A quantum dot (QD)-conjugated collagen-hyaluronic acid (HA) porous scaffold was combined with our previously reported animal model of mice inferior epigastric flaps and QD infusion to study scaffold angiogenesis. A CdSe/ZnS QD-labeled collagen/HA scaffold was fabricated and examined with a confocal microscope. The degradation rate of the scaffold was inversely related to 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide concentration used in cross-linking. There was no cytotoxicity of the QDs as determined by MTT colorimetric assay. Results of the animal implantation study revealed no difference in acute tissue inflammation between scaffolds with or without QD labeling. To study scaffold angiogenesis, we infused the implanted QD-conjugated collagen/HA scaffold with QD of different fluorescence, which can be simultaneously identified by confocal microscope. By these evaluations, we conclude that QD-conjugated collagen/HA porous scaffold is not different from that without conjugation and can be used in our animal model of scaffold angiogenesis without compromising results.
Authors:
Hsiu-Ting Cheng; Er-Yuan Chuang; Hsu Ma; Chi-Han Tsai; Cherng-Kang Perng
Related Documents :
17085729 - Relationship between bone strength and dual-energy x-ray absorptiometry measurements in...
1563219 - Bone ultrasonic attenuation in women: reproducibility, normal variation and comparison ...
21789959 - Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine.
10441649 - Determination of calcaneal ultrasound properties ex situ: reproducibility, effects of s...
21782779 - Antimicrobial and osteogenic properties of a hydrophilic-modified nanoscale hydroxyapat...
23590559 - Vertical osteoconductivity and early bone formation of titanium-zirconium and titanium ...
14600359 - Effects of lepidium meyenii walp and jatropha macrantha on blood levels of estradiol-17...
15191589 - Histologic evaluation of demineralized freeze-dried bone allografts in barrier membrane...
21460649 - Patient satisfaction in unilateral and bilateral breast reconstruction [outcomes article].
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  69     ISSN:  1536-3708     ISO Abbreviation:  Ann Plast Surg     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  663-7     Citation Subset:  IM    
Affiliation:
From the *Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital; and †Institute of Biomedical Engineering, National Yang-Ming University, Taipei City, Taiwan, Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adipose-derived stem cells seeded on acellular dermal matrix grafts enhance wound healing in a murin...
Next Document:  MicroRNA Signatures in Ischemia-Reperfusion Injury.